Inderal and Mania aggravated - a phase IV clinical study of FDA data

Summary:

Mania aggravated is reported as a side effect among people who take Inderal (propranolol hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for 6 - 12 months also take Depakote, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Mania aggravated when taking Inderal. It is created by eHealthMe based on reports of 15,491 people who have side effects when taking Inderal from the FDA, and is updated regularly.

What is Inderal?

Inderal has active ingredients of propranolol hydrochloride. It is often used in migraine. eHealthMe is studying from 16,771 Inderal users. Check the latest studies of Inderal.

What is Mania aggravated?

Mania aggravated (irritable mood) is found to be associated with 815 drugs and 375 conditions by eHealthMe. Check the latest studies of Mania aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

15,491 people reported to have side effects when taking Inderal.
Among them, 56 people (0.36%) have Mania aggravated.

Among these 56 people:

How long have people been on Inderal when they have Mania aggravated? *

What is the gender of people who have Mania aggravated when taking Inderal? *

female: 51.92 %
male: 48.08 %

What is the age of people who have Mania aggravated when taking Inderal? *

What are other drugs people take besides Inderal? *

What are other side effects people have besides Mania aggravated? *

Drowsiness: 18 people, 32.14%
Depression: 16 people, 28.57%
Dizziness: 15 people, 26.79%
Nausea (feeling of having an urge to vomit): 15 people, 26.79%
Weight Increased: 12 people, 21.43%
Fatigue (feeling of tiredness): 12 people, 21.43%
Agitation (state of anxiety or nervous excitement): 11 people, 19.64%
Irritability: 11 people, 19.64%
Hyperhidrosis (abnormally increased sweating): 11 people, 19.64%
Memory Loss: 10 people, 17.86%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 11 people, 19.64%
Panic Disorder: 5 people, 8.93%
Pain: 4 people, 7.14%
Headache (pain in head): 4 people, 7.14%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 7.14%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 4 people, 7.14%
Cyclic Vomiting Syndrome (prolonged episodes of severe nausea, vomiting): 3 people, 5.36%
Quit Smoking: 3 people, 5.36%
Essential Tremor: 3 people, 5.36%
Tardive Dyskinesia (a disorder that involves involuntary movements): 2 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Inderal and have Mania aggravated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Inderal:

Inderal (16,771 reports)

Browse all side effects of Inderal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania aggravated:

Mania aggravated (815 drugs)

Browse all the conditions that are associated with Mania aggravated:

Mania aggravated (375 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on propranolol hydrochloride (the active ingredients of Inderal) and Inderal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.