Inspra and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Inspra (eplerenone), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Potassium, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Oedema when taking Inspra. It is created by eHealthMe based on reports of 3,456 people who have side effects when taking Inspra from the FDA, and is updated regularly.

What is Inspra?

Inspra has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 3,510 Inspra users. Check the latest studies of Inspra.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,171 drugs and 2,311 conditions by eHealthMe. Check the latest studies of Oedema.

On Jul, 20, 2026

3,456 people reported to have side effects when taking Inspra.
Among them, 38 people (1.1%) have Oedema.

Among these 38 people:

How long have people been on Inspra when they have Oedema? *

What is the gender of people who have Oedema when taking Inspra? *

female: 32.43 %
male: 67.57 %

What is the age of people who have Oedema when taking Inspra? *

What are other drugs people take besides Inspra? *

Potassium: 12 people, 31.58%
Adcirca: 11 people, 28.95%
Zaroxolyn: 9 people, 23.68%
Ambien: 9 people, 23.68%
Opsumit: 9 people, 23.68%
Flonase: 8 people, 21.05%
Furosemide: 7 people, 18.42%
Letairis: 7 people, 18.42%
Lasix: 6 people, 15.79%
Oxycodone And Acetaminophen: 6 people, 15.79%

What are other side effects people have besides Oedema? *

Dyspnea (difficult or laboured breathing): 18 people, 47.37%
Diarrhea: 14 people, 36.84%
Acute Kidney Failure: 14 people, 36.84%
Pain In Extremity: 13 people, 34.21%
Oedema Peripheral (superficial swelling): 11 people, 28.95%
Cough: 10 people, 26.32%
Blood Creatinine Increased: 9 people, 23.68%
Hypotension (abnormally low blood pressure): 8 people, 21.05%
Weight Increased: 8 people, 21.05%
Cardiac Failure: 8 people, 21.05%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 16 people, 42.11%
Cardiac Failure: 5 people, 13.16%
Arrhythmias (irregular heartbeat): 4 people, 10.53%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 10.53%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 10.53%
Cardiac Failure Congestive: 4 people, 10.53%
Heart Attack: 2 people, 5.26%
Stress And Anxiety: 2 people, 5.26%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Inspra and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Inspra:

Inspra (3,510 reports)

Oedema treatments and more:

Oedema (78,747 reports)

Browse all side effects of Inspra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,171 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,311 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on eplerenone (the active ingredients of Inspra) and Inspra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.