Invokamet and Nausea and vomiting - a phase IV clinical study of FDA data

Summary:

Nausea and vomiting is reported as a side effect among people who take Invokamet (canagliflozin; metformin hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Amlodipine, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Nausea and vomiting when taking Invokamet. It is created by eHealthMe based on reports of 1,957 people who have side effects when taking Invokamet from the FDA, and is updated regularly.

What is Invokamet?

Invokamet has active ingredients of canagliflozin; metformin hydrochloride. eHealthMe is studying from 1,965 Invokamet users. Check the latest studies of Invokamet.

What is Nausea and vomiting?

Nausea and vomiting is found to be associated with 3,711 drugs and 5,745 conditions by eHealthMe. Check the latest studies of Nausea and vomiting.

On Aug, 11, 2026

1,957 people reported to have side effects when taking Invokamet.
Among them, 56 people (2.86%) have Nausea and vomiting.

Could Invokamet cause Nausea and vomiting?

Among these 56 people:

How long have people been on Invokamet when they have Nausea and vomiting? *

What is the gender of people who have Nausea and vomiting when taking Invokamet? *

female: 77.36 %
male: 22.64 %

What is the age of people who have Nausea and vomiting when taking Invokamet? *

What are other drugs people take besides Invokamet? *

What are other side effects people have besides Nausea and vomiting? *

Nausea (feeling of having an urge to vomit): 34 people, 60.71%
Diarrhea: 15 people, 26.79%
Headache (pain in head): 9 people, 16.07%
Abdominal Discomfort: 7 people, 12.50%
Flatulence (flatus expelled through the anus): 7 people, 12.50%
Dizziness: 7 people, 12.50%
Fatigue (feeling of tiredness): 7 people, 12.50%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 5 people, 8.93%
Indigestion: 5 people, 8.93%
Weight Decreased: 5 people, 8.93%

What are the existing conditions these people have? *

Type 2 Diabetes: 20 people, 35.71%
Diabetes: 14 people, 25.00%
High Blood Pressure: 8 people, 14.29%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.93%
High Blood Cholesterol: 4 people, 7.14%
Cushing's Syndrome (obesity, a rounded face, increased fat): 3 people, 5.36%
Weight Loss: 1 person, 1.79%
Insulin Resistance: 1 person, 1.79%
Blood Glucose Abnormal: 1 person, 1.79%
Blood Pressure Abnormal: 1 person, 1.79%

* Approximation only. Some reports may have incomplete information.

Do you take Invokamet and have Nausea and vomiting?

- Check whether Nausea and vomiting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Invokamet:

Invokamet (1,965 reports)

Nausea and vomiting treatments and more:

Nausea and vomiting (529,395 reports)

How severe was Nausea and vomiting and when was it recovered:

Nausea and vomiting in Invokamet

Expand to all the drugs that have ingredients of canagliflozin; metformin hydrochloride:

Nausea and vomiting and drugs with ingredients of canagliflozin; metformin hydrochloride (56 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Invokamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nausea and vomiting:

Nausea and vomiting (3,711 drugs)

Browse all the conditions that are associated with Nausea and vomiting:

Nausea and vomiting (5,745 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on canagliflozin; metformin hydrochloride (the active ingredients of Invokamet) and Invokamet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.