Irinotecan hydrochloride and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Irinotecan hydrochloride (irinotecan hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Prednisone, and have Glioblastoma multiforme.

The phase IV clinical study analyzes which people have Mental status changes when taking Irinotecan hydrochloride. It is created by eHealthMe based on reports of 7,131 people who have side effects when taking Irinotecan hydrochloride from the FDA, and is updated regularly.

What is Irinotecan hydrochloride?

Irinotecan hydrochloride has active ingredients of irinotecan hydrochloride. It is often used in cancer. eHealthMe is studying from 7,166 Irinotecan hydrochloride users. Check the latest studies of Irinotecan hydrochloride.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,500 drugs and 1,759 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Jul, 04, 2026

7,131 people reported to have side effects when taking Irinotecan hydrochloride.
Among them, 12 people (0.17%) have Mental status changes.

Could Irinotecan hydrochloride cause Mental status changes?

Among these 12 people:

How long have people been on Irinotecan hydrochloride when they have Mental status changes? *

What is the gender of people who have Mental status changes when taking Irinotecan hydrochloride? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Mental status changes when taking Irinotecan hydrochloride? *

What are other drugs people take besides Irinotecan hydrochloride? *

Synthroid: 6 people, 50.00%
Enoxaparin Sodium: 6 people, 50.00%
Prednisone: 6 people, 50.00%
Fludrocortisone Acetate: 5 people, 41.67%
Warfarin Sodium: 5 people, 41.67%
Oxycontin: 5 people, 41.67%
Decadron: 4 people, 33.33%
Prevacid: 4 people, 33.33%
Paxil: 4 people, 33.33%
Topamax: 4 people, 33.33%

What are other side effects people have besides Mental status changes? *

Drowsiness: 7 people, 58.33%
Speech Impairment (Adult) (inability to speak (adult)): 7 people, 58.33%
Speech Disorder: 7 people, 58.33%
Confusional State: 7 people, 58.33%
Weight Decreased: 6 people, 50.00%
Cerebral Haemorrhage (bleeding within the brain): 6 people, 50.00%
Cerebral Ischaemia (insufficient blood flow to the brain to meet metabolic demand): 6 people, 50.00%
Headache (pain in head): 6 people, 50.00%
Neuropathy Peripheral (surface nerve damage): 6 people, 50.00%
Encephalopathy (functioning of the brain is affected by some agent or condition): 6 people, 50.00%

What are the existing conditions these people have? *

Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 5 people, 41.67%
Pain: 2 people, 16.67%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 1 person, 8.33%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 1 person, 8.33%
Neuroblastoma (a cancer that forms in your nerve tissue): 1 person, 8.33%
Neuralgia (pain in one or more nerves): 1 person, 8.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%
Itching: 1 person, 8.33%
Fever: 1 person, 8.33%
Diarrhea: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Irinotecan hydrochloride and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Irinotecan hydrochloride:

Irinotecan hydrochloride (7,166 reports)

Browse all side effects of Irinotecan hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,500 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on irinotecan hydrochloride (the active ingredients of Irinotecan hydrochloride) and Irinotecan hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.