Isosorbide dinitrate and Shock - a phase IV clinical study of FDA data

Summary:

Shock is reported as a side effect among people who take Isosorbide dinitrate (isosorbide dinitrate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Shock when taking Isosorbide dinitrate. It is created by eHealthMe based on reports of 13,073 people who have side effects when taking Isosorbide dinitrate from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

What is Shock?

Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin) is found to be associated with 1,213 drugs and 1,755 conditions by eHealthMe. Check the latest studies of Shock.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

13,073 people reported to have side effects when taking Isosorbide dinitrate.
Among them, 89 people (0.68%) have Shock.

Among these 89 people:

How long have people been on Isosorbide dinitrate when they have Shock? *

What is the gender of people who have Shock when taking Isosorbide dinitrate? *

female: 42.86 %
male: 57.14 %

What is the age of people who have Shock when taking Isosorbide dinitrate? *

What are other drugs people take besides Isosorbide dinitrate? *

Amlodipine: 18 people, 20.22%
Furosemide: 16 people, 17.98%
Aspirin: 12 people, 13.48%
Famotidine: 10 people, 11.24%
Carvedilol: 9 people, 10.11%
Diltiazem Hydrochloride: 8 people, 8.99%
Nifedipine: 8 people, 8.99%
Allopurinol: 7 people, 7.87%
Spironolactone: 6 people, 6.74%
Lansoprazole: 6 people, 6.74%

What are other side effects people have besides Shock? *

Bradycardia (abnormally slow heart action): 27 people, 30.34%
Hyperkalemia (damage to or disease of the kidney): 25 people, 28.09%
Lactic Acidosis (low ph in body tissues): 22 people, 24.72%
Acute Kidney Failure: 14 people, 15.73%
Hypotension (abnormally low blood pressure): 14 people, 15.73%
Depressed Level Of Consciousness: 10 people, 11.24%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 10 people, 11.24%
Blood Creatinine Increased: 9 people, 10.11%
Thrombocytopenia (decrease of platelets in blood): 9 people, 10.11%
Atrioventricular Block (heart block): 9 people, 10.11%

What are the existing conditions these people have? *

Type 2 Diabetes: 10 people, 11.24%
Cardiac Failure: 7 people, 7.87%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 6.74%
Pneumonia: 5 people, 5.62%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 5.62%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 4.49%
Cardiac Failure Congestive: 4 people, 4.49%
Gastritis (inflammation of stomach): 4 people, 4.49%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 4 people, 4.49%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 4.49%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide dinitrate and have Shock?

- Check whether Shock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isosorbide dinitrate:

Isosorbide dinitrate (13,180 reports)

Shock treatments and more:

Shock (28,534 reports)

Browse all side effects of Isosorbide dinitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Shock:

Shock (1,213 drugs)

Browse all the conditions that are associated with Shock:

Shock (1,755 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide dinitrate (the active ingredients of Isosorbide dinitrate) and Isosorbide dinitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.