Isosorbide dinitrate and Sudden death unexplained - a phase IV clinical study of FDA data

Summary:

Sudden death unexplained is reported as a side effect among people who take Isosorbide dinitrate (isosorbide dinitrate), especially for people who are male, 60+ old, also take Viagra,.

The study is created by eHealthMe based on reports of 13,073 people who have side effects when taking Isosorbide dinitrate from the FDA, and is updated regularly.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 15, 2026

13,073 people reported to have side effects when taking Isosorbide dinitrate.
Among them, 11 people (0.08%) died.

Could Isosorbide dinitrate cause Sudden death unexplained?

Among these 11 people:

What is the gender of people who died when taking Isosorbide dinitrate? *

female: 18.18 %
male: 81.82 %

What is the age of people who died when taking Isosorbide dinitrate? *

What are other drugs people take besides Isosorbide dinitrate? *

What are other side effects people have before they died? *

Heart Attack: 5 people, 45.45%
Weakness: 1 person, 9.09%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 1 person, 9.09%
Ventricular Fibrillation (abnormally irregular heart rhythm): 1 person, 9.09%
Ventricle Rupture (heart rupture): 1 person, 9.09%
Renal Failure Aggravated: 1 person, 9.09%
Itching: 1 person, 9.09%
Hepatomegaly (abnormal enlargement of the liver): 1 person, 9.09%
Hepatic Failure (liver failure): 1 person, 9.09%
Dyspnea Exertional: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isosorbide dinitrate:

Isosorbide dinitrate (13,180 reports)

Expand to all the drugs that have ingredients of isosorbide dinitrate:

Sudden death unexplained and drugs with ingredients of isosorbide dinitrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Isosorbide dinitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sudden death unexplained:

Sudden death unexplained (184 drugs)

Browse all the conditions that are associated with Sudden death unexplained:

Sudden death unexplained (24 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide dinitrate (the active ingredients of Isosorbide dinitrate) and Isosorbide dinitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.