Isosorbide mononitrate and Akathisia - a phase IV clinical study of FDA data

Summary:

Akathisia is reported as a side effect among people who take Isosorbide mononitrate (isosorbide mononitrate), especially for people who are female, 40-49 old, also take Aspirin, and have Depression.

The phase IV clinical study analyzes which people have Akathisia when taking Isosorbide mononitrate. It is created by eHealthMe based on reports of 26,444 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Akathisia?

Akathisia (a movement disorder characterized by a feeling of inner restlessness) is found to be associated with 442 drugs and 825 conditions by eHealthMe. Check the latest studies of Akathisia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

26,444 people reported to have side effects when taking Isosorbide mononitrate.
Among them, 23 people (0.09%) have Akathisia.

Could Isosorbide mononitrate cause Akathisia?

Among these 23 people:

What is the gender of people who have Akathisia when taking Isosorbide mononitrate? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Akathisia when taking Isosorbide mononitrate? *

What are other drugs people take besides Isosorbide mononitrate? *

Aspirin: 20 people, 86.96%
Simvastatin: 17 people, 73.91%
Atenolol: 15 people, 65.22%
Felodipine: 14 people, 60.87%
Propofol: 14 people, 60.87%
Rocuronium Bromide: 14 people, 60.87%
Morphine: 13 people, 56.52%
Citalopram Hydrobromide: 12 people, 52.17%
Dexamethasone: 9 people, 39.13%
Alfentanil: 7 people, 30.43%

What are other side effects people have besides Akathisia? *

Blood Phosphorus Increased: 14 people, 60.87%
White Blood Cell Count Increased: 13 people, 56.52%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 13 people, 56.52%
Agitation (state of anxiety or nervous excitement): 13 people, 56.52%
Glasgow Coma Scale Abnormal: 12 people, 52.17%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 12 people, 52.17%
Pupillary Reflex Impaired: 12 people, 52.17%
Blood Calcium Increased: 12 people, 52.17%
Mydriasis (a dilation of the pupil): 11 people, 47.83%
Staring (a prolonged gaze or fixed look): 11 people, 47.83%

What are the existing conditions these people have? *

Depression: 13 people, 56.52%
Sedation: 10 people, 43.48%
Analgesia: 10 people, 43.48%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 13.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide mononitrate and have Akathisia?

- Check whether Akathisia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isosorbide mononitrate:

Isosorbide mononitrate (26,858 reports)

Akathisia treatments and more:

Akathisia (15,139 reports)

Browse all side effects of Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Akathisia:

Akathisia (442 drugs)

Browse all the conditions that are associated with Akathisia:

Akathisia (825 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide mononitrate (the active ingredients of Isosorbide mononitrate) and Isosorbide mononitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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