Isosorbide mononitrate and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Isosorbide mononitrate (isosorbide mononitrate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Enalapril Maleate, and have Metastatic renal cell carcinoma.

The phase IV clinical study analyzes which people have Hepatic failure when taking Isosorbide mononitrate. It is created by eHealthMe based on reports of 26,444 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,539 drugs and 1,894 conditions by eHealthMe. Check the latest studies of Hepatic failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

26,444 people reported to have side effects when taking Isosorbide mononitrate.
Among them, 86 people (0.33%) have Hepatic failure.

Could Isosorbide mononitrate cause Hepatic failure?

Among these 86 people:

How long have people been on Isosorbide mononitrate when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Isosorbide mononitrate? *

female: 30.12 %
male: 69.88 %

What is the age of people who have Hepatic failure when taking Isosorbide mononitrate? *

What are other drugs people take besides Isosorbide mononitrate? *

What are other side effects people have besides Hepatic failure? *

Acute Kidney Failure: 33 people, 38.37%
Thrombocytopenia (decrease of platelets in blood): 23 people, 26.74%
Encephalopathy (functioning of the brain is affected by some agent or condition): 18 people, 20.93%
Cardiac Failure Congestive: 16 people, 18.60%
Sepsis (a severe blood infection that can lead to organ failure and death): 15 people, 17.44%
Multi-Organ Failure (multisystem organ failure): 14 people, 16.28%
Gallstones (stone formation by bile component): 13 people, 15.12%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 13.95%
Nausea (feeling of having an urge to vomit): 12 people, 13.95%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 12 people, 13.95%

What are the existing conditions these people have? *

Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 9 people, 10.47%
High Blood Cholesterol: 7 people, 8.14%
Depression: 5 people, 5.81%
Oesophageal Candidiasis (fungal infection of oesophagus): 3 people, 3.49%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 3.49%
Type 2 Diabetes: 2 people, 2.33%
Diabetes: 2 people, 2.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 2.33%
Ill-Defined Disorder: 2 people, 2.33%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 1.16%

* Approximation only. Some reports may have incomplete information.

Do you take Isosorbide mononitrate and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Isosorbide mononitrate:

Isosorbide mononitrate (26,858 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

Browse all side effects of Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,539 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,894 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide mononitrate (the active ingredients of Isosorbide mononitrate) and Isosorbide mononitrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.