Janumet and Hyperthyroid - a phase IV clinical study of FDA data

Summary:

Hyperthyroid is reported as a side effect among people who take Janumet (metformin hydrochloride; sitagliptin phosphate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Cymbalta, and have Hepatocellular carcinoma.

The phase IV clinical study analyzes which people have Hyperthyroid when taking Janumet. It is created by eHealthMe based on reports of 24,406 people who have side effects when taking Janumet from the FDA, and is updated regularly.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

What is Hyperthyroid?

Hyperthyroid is found to be associated with 1,138 drugs and 1,409 conditions by eHealthMe. Check the latest studies of Hyperthyroid.

On Oct, 20, 2025

24,406 people reported to have side effects when taking Janumet.
Among them, 14 people (0.06%) have Hyperthyroid.

Among these 14 people:

How long have people been on Janumet when they have Hyperthyroid? *

What is the gender of people who have Hyperthyroid when taking Janumet? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Hyperthyroid when taking Janumet? *

What are other drugs people take besides Janumet? *

What are other side effects people have besides Hyperthyroid? *

High Blood Pressure: 7 people, 50.00%
Fatigue (feeling of tiredness): 4 people, 28.57%
Insomnia (sleeplessness): 4 people, 28.57%
Conjunctivitis (pink eye): 4 people, 28.57%
Chest Pain: 3 people, 21.43%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 21.43%
Gallstones (stone formation by bile component): 3 people, 21.43%
Pneumonia: 3 people, 21.43%
Depression: 3 people, 21.43%
Metastases To Liver (cancer spreads to liver): 3 people, 21.43%

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 14.29%
Herpes Zoster: 2 people, 14.29%
Hepatocellular Carcinoma (liver cancer): 2 people, 14.29%
Post Procedural Hypothyroidism: 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Janumet and have Hyperthyroid?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Janumet:

Janumet (25,023 reports)

Hyperthyroid treatments and more:

Hyperthyroid (26,828 reports)

How severe was Hyperthyroid and when was it recovered:

Hyperthyroid in Janumet

Expand to all the drugs that have ingredients of metformin hydrochloride; sitagliptin phosphate:

Hyperthyroid and drugs with ingredients of metformin hydrochloride; sitagliptin phosphate (6 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Janumet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperthyroid:

Hyperthyroid (1,138 drugs)

Browse all the conditions that are associated with Hyperthyroid:

Hyperthyroid (1,409 conditions)

Drugs similar to Janumet and Hyperthyroid :

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride; sitagliptin phosphate (the active ingredients of Janumet) and Janumet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.