1. Home
  2. Analysis
  3. Januvia
  4. Knee-joint-replacement

Januvia and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Januvia (sitagliptin phosphate), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Metformin, and have High blood pressure.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Januvia. It is created by eHealthMe based on reports of 71,642 people who have side effects when taking Januvia from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 948 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 04, 2026

71,642 people reported to have side effects when taking Januvia.
Among them, 95 people (0.13%) have Knee joint replacement.

Could Januvia cause Knee joint replacement?

Among these 95 people:

How long have people been on Januvia when they have Knee joint replacement? *

  • < 1 month: 3.23 %
  • 1 - 6 months: 6.45 %
  • 6 - 12 months: 22.58 %
  • 1 - 2 years: 32.26 %
  • 2 - 5 years: 29.03 %
  • 5 - 10 years: 6.45 %
  • 10+ years: 0.0 %

What is the gender of people who have Knee joint replacement when taking Januvia? *

  • female: 60.87 %
  • male: 39.13 %

What is the age of people who have Knee joint replacement when taking Januvia? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 2.38 %
  • 50-59: 9.52 %
  • 60+: 88.1 %

What are other drugs people take besides Januvia? *

  1. Metformin: 15 people, 15.79%
  2. Humira: 8 people, 8.42%
  3. Celebrex: 7 people, 7.37%
  4. Lisinopril: 6 people, 6.32%
  5. Byetta: 6 people, 6.32%
  6. Lipitor: 5 people, 5.26%
  7. Norvasc: 5 people, 5.26%
  8. Actos: 5 people, 5.26%
  9. Vitamin D: 5 people, 5.26%
  10. Vitamin D3: 5 people, 5.26%

What are other side effects people have besides Knee joint replacement? *

  1. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 20 people, 21.05%
  2. Adenocarcinoma Pancreas (cancer of pancreas): 18 people, 18.95%
  3. High Blood Pressure: 16 people, 16.84%
  4. Joint Pain: 15 people, 15.79%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 14.74%
  6. Depression: 14 people, 14.74%
  7. Back Pain: 14 people, 14.74%
  8. Stress And Anxiety: 13 people, 13.68%
  9. Hyperlipidaemia (presence of excess lipids in the blood): 13 people, 13.68%
  10. Metastases To Liver (cancer spreads to liver): 13 people, 13.68%

What are the existing conditions these people have? *

  1. High Blood Pressure: 11 people, 11.58%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 9.47%
  3. Psoriasis (immune-mediated disease that affects the skin): 8 people, 8.42%
  4. Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 5.26%
  5. High Blood Cholesterol: 5 people, 5.26%
  6. Type 1 Diabetes: 4 people, 4.21%
  7. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 4.21%
  8. Hyperkalemia (damage to or disease of the kidney): 3 people, 3.16%
  9. Joint Pain: 3 people, 3.16%
  10. Osteoporosis (bones weak and more likely to break): 3 people, 3.16%

* Approximation only. Some reports may have incomplete information.

Do you take Januvia and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Januvia:

Knee joint replacement treatments and more:

How severe was Knee joint replacement and when was it recovered:

Expand to all the drugs that have ingredients of sitagliptin phosphate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Januvia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Browse all the conditions that are associated with Knee joint replacement:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sitagliptin phosphate (the active ingredients of Januvia) and Januvia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.