Januvia and Polycythaemia - a phase IV clinical study of FDA data

Summary:

Polycythaemia is reported as a side effect among people who take Januvia (sitagliptin phosphate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Metformin, and have High blood pressure.

The phase IV clinical study analyzes which people have Polycythaemia when taking Januvia. It is created by eHealthMe based on reports of 71,642 people who have side effects when taking Januvia from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Polycythaemia?

Polycythaemia (proportion of blood volume that is occupied by red blood cells increases) is found to be associated with 278 drugs and 448 conditions by eHealthMe. Check the latest studies of Polycythaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

71,642 people reported to have side effects when taking Januvia.
Among them, 12 people (0.02%) have Polycythaemia.

Among these 12 people:

How long have people been on Januvia when they have Polycythaemia? *

What is the gender of people who have Polycythaemia when taking Januvia? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Polycythaemia when taking Januvia? *

What are other drugs people take besides Januvia? *

What are other side effects people have besides Polycythaemia? *

Nausea (feeling of having an urge to vomit): 4 people, 33.33%
Weakness: 3 people, 25.00%
High Blood Pressure: 3 people, 25.00%
Fatigue (feeling of tiredness): 3 people, 25.00%
Sleep Apnea Syndrome: 2 people, 16.67%
Back Pain: 2 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
Arrhythmias (irregular heartbeat): 2 people, 16.67%
Rashes (redness): 2 people, 16.67%
Cardiac Failure Congestive: 2 people, 16.67%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 25.00%
Renal Cell Carcinoma (a kidney cancer): 2 people, 16.67%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 1 person, 8.33%
Sleep Disorder: 1 person, 8.33%
Rickets (softening of bones): 1 person, 8.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 8.33%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 1 person, 8.33%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Januvia and have Polycythaemia?

- Check whether Polycythaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Januvia:

Januvia (72,818 reports)

Polycythaemia treatments and more:

Polycythaemia (3,051 reports)

Browse all side effects of Januvia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polycythaemia:

Polycythaemia (278 drugs)

Browse all the conditions that are associated with Polycythaemia:

Polycythaemia (448 conditions)

Related publications that referenced our studies

Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .

How the study uses the data?

The study uses data from the FDA. It is based on sitagliptin phosphate (the active ingredients of Januvia) and Januvia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.