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Januvia and Wax blockage - a phase IV clinical study of FDA data

Summary:

Wax blockage is reported as a side effect among people who take Januvia (sitagliptin phosphate), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Digoxin, and have Dry eyes.

The phase IV clinical study analyzes which people have Wax blockage when taking Januvia. It is created by eHealthMe based on reports of 71,642 people who have side effects when taking Januvia from the FDA, and is updated regularly.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

What is Wax blockage?

Wax blockage is found to be associated with 410 drugs and 972 conditions by eHealthMe. Check the latest studies of Wax blockage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

71,642 people reported to have side effects when taking Januvia.
Among them, 16 people (0.02%) have Wax blockage.

Could Januvia cause Wax blockage?

Among these 16 people:

How long have people been on Januvia when they have Wax blockage? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 12.5 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 50.0 %
  • 2 - 5 years: 25.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Wax blockage when taking Januvia? *

  • female: 6.25 %
  • male: 93.75 %

What is the age of people who have Wax blockage when taking Januvia? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 38.46 %
  • 60+: 61.54 %

What are other drugs people take besides Januvia? *

  1. Digoxin: 8 people, 50.00%
  2. Glucotrol: 7 people, 43.75%
  3. Coumadin: 7 people, 43.75%
  4. Gabapentin: 7 people, 43.75%
  5. Ambien: 7 people, 43.75%
  6. Norvasc: 7 people, 43.75%
  7. Mirtazapine: 7 people, 43.75%
  8. Spiriva: 7 people, 43.75%
  9. Combivent: 6 people, 37.50%
  10. Furosemide: 5 people, 31.25%

What are other side effects people have besides Wax blockage? *

  1. Acute Kidney Failure: 9 people, 56.25%
  2. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 50.00%
  3. Heart Attack: 7 people, 43.75%
  4. Insomnia (sleeplessness): 7 people, 43.75%
  5. Urinary Retention (the inability to completely or partially empty the bladder): 7 people, 43.75%
  6. Constipation: 7 people, 43.75%
  7. Pleural Effusion (water on the lungs): 7 people, 43.75%
  8. Psoriasis (immune-mediated disease that affects the skin): 6 people, 37.50%
  9. Hypoaesthesia (reduced sense of touch or sensation): 6 people, 37.50%
  10. Multiple Injuries: 6 people, 37.50%

What are the existing conditions these people have? *

  1. Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 4 people, 25.00%
  2. Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 4 people, 25.00%
  3. Hyperkalemia (damage to or disease of the kidney): 4 people, 25.00%
  4. Headache (pain in head): 4 people, 25.00%
  5. Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 4 people, 25.00%
  6. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 25.00%
  7. Gastric Ulcer (stomach ulcer): 4 people, 25.00%
  8. Fever: 4 people, 25.00%
  9. Febrile Neutropenia (fever with reduced white blood cells): 4 people, 25.00%
  10. Dry Eyes (lack of adequate tears): 4 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Januvia and have Wax blockage?

- Check whether Wax blockage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Januvia:

Wax blockage treatments and more:

How severe was Wax blockage and when was it recovered:

Expand to all the drugs that have ingredients of sitagliptin phosphate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Januvia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Wax blockage:

Browse all the conditions that are associated with Wax blockage:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sitagliptin phosphate (the active ingredients of Januvia) and Januvia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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