Jardiance and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Jardiance (empagliflozin), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Lisinopril, and have Diabetes.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Jardiance. It is created by eHealthMe based on reports of 43,725 people who have side effects when taking Jardiance from the FDA, and is updated regularly.

What is Jardiance?

Jardiance has active ingredients of empagliflozin. It is often used in hyperglycemia. eHealthMe is studying from 44,460 Jardiance users. Check the latest studies of Jardiance.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 774 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

43,725 people reported to have side effects when taking Jardiance.
Among them, 12 people (0.03%) have Hyperkeratosis.

Among these 12 people:

How long have people been on Jardiance when they have Hyperkeratosis? *

What is the gender of people who have Hyperkeratosis when taking Jardiance? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Hyperkeratosis when taking Jardiance? *

What are other drugs people take besides Jardiance? *

What are other side effects people have besides Hyperkeratosis? *

Blood Glucose Increased: 5 people, 41.67%
Drug Ineffective: 4 people, 33.33%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 25.00%
Injection Site Pruritus (severe itching at injection site): 3 people, 25.00%
Hypertriglyceridaemia (excess of triglycerides in the blood): 3 people, 25.00%
Back Pain: 3 people, 25.00%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 3 people, 25.00%
Chlamydial Infection (a common sexually transmitted infection (sti) in humans caused by the bacterium chlamydia trachomatis): 3 people, 25.00%
Injection Site Irritation: 3 people, 25.00%
Fatigue (feeling of tiredness): 3 people, 25.00%

What are the existing conditions these people have? *

Diabetes: 7 people, 58.33%
High Blood Pressure: 5 people, 41.67%
Joint Pain: 4 people, 33.33%
Depression: 4 people, 33.33%
Hypertriglyceridaemia (excess of triglycerides in the blood): 4 people, 33.33%
Nausea (feeling of having an urge to vomit): 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
Type 2 Diabetes: 3 people, 25.00%
Vitamin D Decreased: 3 people, 25.00%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Jardiance and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Jardiance:

Jardiance (44,460 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Jardiance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (774 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on empagliflozin (the active ingredients of Jardiance) and Jardiance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.