Jardiance and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Jardiance (empagliflozin), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Jakafi, and have Primary myelofibrosis.

The phase IV clinical study analyzes which people have Splenomegaly when taking Jardiance. It is created by eHealthMe based on reports of 43,725 people who have side effects when taking Jardiance from the FDA, and is updated regularly.

What is Jardiance?

Jardiance has active ingredients of empagliflozin. It is often used in hyperglycemia. eHealthMe is studying from 44,457 Jardiance users. Check the latest studies of Jardiance.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,122 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jun, 02, 2026

43,725 people reported to have side effects when taking Jardiance.
Among them, 16 people (0.04%) have Splenomegaly.

Among these 16 people:

How long have people been on Jardiance when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Jardiance? *

female: 30 %
male: 70 %

What is the age of people who have Splenomegaly when taking Jardiance? *

What are other drugs people take besides Jardiance? *

What are other side effects people have besides Splenomegaly? *

Haemoglobin Decreased: 6 people, 37.50%
Fatigue (feeling of tiredness): 5 people, 31.25%
Weight Increased: 4 people, 25.00%
Diarrhea: 4 people, 25.00%
Weakness: 4 people, 25.00%
Anaemia (lack of blood): 4 people, 25.00%
Thrombocytopenia (decrease of platelets in blood): 4 people, 25.00%
Gallstones (stone formation by bile component): 4 people, 25.00%
Cough: 4 people, 25.00%
Joint Pain: 3 people, 18.75%

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 31.25%
Pain: 3 people, 18.75%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 12.50%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 12.50%
Diabetes: 2 people, 12.50%
Type 2 Diabetes: 1 person, 6.25%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 6.25%
Nausea (feeling of having an urge to vomit): 1 person, 6.25%
Liver Disorder (liver diseases): 1 person, 6.25%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Jardiance and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Jardiance:

Jardiance (44,457 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Jardiance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,122 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on empagliflozin (the active ingredients of Jardiance) and Jardiance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.