Jetrea and Macular hole - a phase IV clinical study of FDA data

Summary:

Macular hole is reported as a side effect among people who take Jetrea (ocriplasmin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Levoxyl, and have Vitreous adhesions.

The phase IV clinical study analyzes which people have Macular hole when taking Jetrea. It is created by eHealthMe based on reports of 718 people who have side effects when taking Jetrea from the FDA, and is updated regularly.

What is Jetrea?

Jetrea has active ingredients of ocriplasmin. eHealthMe is studying from 719 Jetrea users. Check the latest studies of Jetrea.

What is Macular hole?

Macular hole (small break in the macula, the central area of the retina) is found to be associated with 177 drugs and 526 conditions by eHealthMe. Check the latest studies of Macular hole.

On Jul, 07, 2026

718 people reported to have side effects when taking Jetrea.
Among them, 82 people (11.42%) have Macular hole.

Among these 82 people:

How long have people been on Jetrea when they have Macular hole? *

What is the gender of people who have Macular hole when taking Jetrea? *

female: 92.16 %
male: 7.84 %

What is the age of people who have Macular hole when taking Jetrea? *

What are other drugs people take besides Jetrea? *

What are other side effects people have besides Macular hole? *

Visual Acuity Reduced (reduced clearness of vision): 53 people, 64.63%
Disease Progression: 40 people, 48.78%
Photopsia (presence of perceived flashes of light): 29 people, 35.37%
Vision Blurred: 23 people, 28.05%
Retinal Injury (injury to retina): 22 people, 26.83%
Vitreous Floaters (spots before the eyes): 20 people, 24.39%
Photophobia (extreme sensitivity to light): 17 people, 20.73%
Visual Impairment: 16 people, 19.51%
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank): 16 people, 19.51%
Pupillary Reflex Impaired: 13 people, 15.85%

What are the existing conditions these people have? *

Vitreous Adhesions: 54 people, 65.85%
High Blood Pressure: 8 people, 9.76%
High Blood Cholesterol: 7 people, 8.54%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.10%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 3.66%
Diabetes: 3 people, 3.66%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 3.66%
Seasonal Allergy (allergic condition due to certain season): 2 people, 2.44%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 2.44%
Neuropathy Peripheral (surface nerve damage): 2 people, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Jetrea and have Macular hole?

- Check whether Macular hole is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Jetrea:

Jetrea (719 reports)

Macular hole treatments and more:

Macular hole (1,673 reports)

Browse all side effects of Jetrea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macular hole:

Macular hole (177 drugs)

Browse all the conditions that are associated with Macular hole:

Macular hole (526 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ocriplasmin (the active ingredients of Jetrea) and Jetrea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.