Kadcyla and Lymphoedema - a phase IV clinical study of FDA data

Summary:

Lymphoedema is reported as a side effect among people who take Kadcyla (ado-trastuzumab emtansine), especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months also take Xeloda, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Lymphoedema when taking Kadcyla. It is created by eHealthMe based on reports of 5,798 people who have side effects when taking Kadcyla from the FDA, and is updated regularly.

What is Kadcyla?

Kadcyla has active ingredients of ado-trastuzumab emtansine. eHealthMe is studying from 5,813 Kadcyla users. Check the latest studies of Kadcyla.

What is Lymphoedema?

Lymphoedema (localized fluid retention and tissue swelling) is found to be associated with 912 drugs and 743 conditions by eHealthMe. Check the latest studies of Lymphoedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

5,798 people reported to have side effects when taking Kadcyla.
Among them, 61 people (1.05%) have Lymphoedema.

Among these 61 people:

How long have people been on Kadcyla when they have Lymphoedema? *

What is the gender of people who have Lymphoedema when taking Kadcyla? *

female: 56 %
male: 44 %

What is the age of people who have Lymphoedema when taking Kadcyla? *

What are other drugs people take besides Kadcyla? *

What are other side effects people have besides Lymphoedema? *

Constipation: 42 people, 68.85%
Fatigue (feeling of tiredness): 41 people, 67.21%
Pain: 41 people, 67.21%
Nausea (feeling of having an urge to vomit): 35 people, 57.38%
Tooth Disorder (tooth disease): 32 people, 52.46%
Fever: 30 people, 49.18%
Weight Decreased: 28 people, 45.90%
Nasopharyngitis (inflammation of the nasopharynx): 28 people, 45.90%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 27 people, 44.26%
Weight Increased: 27 people, 44.26%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 44 people, 72.13%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 13 people, 21.31%
Metastases To Central Nervous System (cancer spreads to central nervous system): 12 people, 19.67%
Headache (pain in head): 12 people, 19.67%
Constipation: 12 people, 19.67%
Breast Cancer: 9 people, 14.75%
Mouth Ulcers: 8 people, 13.11%
Pulmonary Mass: 6 people, 9.84%
Abdominal Pain: 5 people, 8.20%
Pain: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

Do you take Kadcyla and have Lymphoedema?

- Check whether Lymphoedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Kadcyla:

Kadcyla (5,813 reports)

Lymphoedema treatments and more:

Lymphoedema (9,453 reports)

Browse all side effects of Kadcyla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphoedema:

Lymphoedema (912 drugs)

Browse all the conditions that are associated with Lymphoedema:

Lymphoedema (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ado-trastuzumab emtansine (the active ingredients of Kadcyla) and Kadcyla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.