Kaletra and Cognitive disorder - a phase IV clinical study of FDA data

Summary:

Cognitive disorder is reported as a side effect among people who take Kaletra (lopinavir; ritonavir), especially for people who are male, 50-59 old, have been taking the drug for 6 - 12 months also take Cotrim, and have Gastroduodenitis.

The phase IV clinical study analyzes which people have Cognitive disorder when taking Kaletra. It is created by eHealthMe based on reports of 22,879 people who have side effects when taking Kaletra from the FDA, and is updated regularly.

What is Kaletra?

Kaletra has active ingredients of lopinavir; ritonavir. It is often used in hiv infection. eHealthMe is studying from 23,070 Kaletra users. Check the latest studies of Kaletra.

What is Cognitive disorder?

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving) is found to be associated with 1,643 drugs and 1,730 conditions by eHealthMe. Check the latest studies of Cognitive disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

22,879 people reported to have side effects when taking Kaletra.
Among them, 29 people (0.13%) have Cognitive disorder.

Among these 29 people:

How long have people been on Kaletra when they have Cognitive disorder? *

What is the gender of people who have Cognitive disorder when taking Kaletra? *

female: 14.29 %
male: 85.71 %

What is the age of people who have Cognitive disorder when taking Kaletra? *

What are other drugs people take besides Kaletra? *

Fluconazole: 6 people, 20.69%
Omeprazole: 6 people, 20.69%
Cotrim: 6 people, 20.69%
Combivir: 5 people, 17.24%
Truvada: 5 people, 17.24%
Sulfamethoxazole And Trimethoprim: 3 people, 10.34%
Mirtazapine: 3 people, 10.34%
Levetiracetam: 3 people, 10.34%
Abacavir: 2 people, 6.90%
Atenolol: 2 people, 6.90%

What are other side effects people have besides Cognitive disorder? *

Weakness: 14 people, 48.28%
Dizziness: 14 people, 48.28%
Itching: 10 people, 34.48%
Depression: 10 people, 34.48%
Aggression: 9 people, 31.03%
Irritability: 9 people, 31.03%
Confusional State: 8 people, 27.59%
Fever: 7 people, 24.14%
General Physical Health Deterioration (weak health status): 7 people, 24.14%
Whipple's Disease (infection with a bacteria called tropheryma whippelii): 6 people, 20.69%

What are the existing conditions these people have? *

Pharyngitis (inflammation of the pharynx, causing a sore throat): 4 people, 13.79%
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum): 4 people, 13.79%
Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 3 people, 10.34%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 10.34%
Retroviral Infection (viral infection): 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.45%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 3.45%
Fungal Infection: 1 person, 3.45%
Diabetes: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Kaletra and have Cognitive disorder?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Kaletra:

Kaletra (23,070 reports)

Browse all side effects of Kaletra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cognitive disorder:

Cognitive disorder (1,643 drugs)

Browse all the conditions that are associated with Cognitive disorder:

Cognitive disorder (1,730 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lopinavir; ritonavir (the active ingredients of Kaletra) and Kaletra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.