Kaletra and Tibia fracture - a phase IV clinical study of FDA data

Summary:

Tibia fracture is reported as a side effect among people who take Kaletra (lopinavir; ritonavir), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Truvada, and have Pain.

The phase IV clinical study analyzes which people have Tibia fracture when taking Kaletra. It is created by eHealthMe based on reports of 22,879 people who have side effects when taking Kaletra from the FDA, and is updated regularly.

What is Kaletra?

Kaletra has active ingredients of lopinavir; ritonavir. It is often used in hiv infection. eHealthMe is studying from 23,070 Kaletra users. Check the latest studies of Kaletra.

What is Tibia fracture?

Tibia fracture (fracture of lower leg bone) is found to be associated with 643 drugs and 670 conditions by eHealthMe. Check the latest studies of Tibia fracture.

On Aug, 09, 2026

22,879 people reported to have side effects when taking Kaletra.
Among them, 17 people (0.07%) have Tibia fracture.

$Could Kaletra cause Tibia fracture?$

Among these 17 people:

How long have people been on Kaletra when they have Tibia fracture? *

What is the gender of people who have Tibia fracture when taking Kaletra? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Tibia fracture when taking Kaletra? *

What are other drugs people take besides Kaletra? *

What are other side effects people have besides Tibia fracture? *

Osteoporosis (bones weak and more likely to break): 15 people, 88.24%
Pain: 15 people, 88.24%
Stress And Anxiety: 14 people, 82.35%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 14 people, 82.35%
Emotional Distress: 14 people, 82.35%
Fall: 10 people, 58.82%
Lower Limb Fracture: 10 people, 58.82%
Upper Limb Fracture: 8 people, 47.06%
Foot Fracture: 7 people, 41.18%
Pain In Extremity: 5 people, 29.41%

What are the existing conditions these people have? *

Pain: 2 people, 11.76%
Urinary Retention (the inability to completely or partially empty the bladder): 1 person, 5.88%
Insomnia (sleeplessness): 1 person, 5.88%
Hiv Test Positive: 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%
Gastric Disorder (disease of stomach): 1 person, 5.88%
Fungal Infection: 1 person, 5.88%
Dyspnea (difficult or laboured breathing): 1 person, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Kaletra and have Tibia fracture?

- Check whether Tibia fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Kaletra:

Kaletra (23,070 reports)

Tibia fracture treatments and more:

Tibia fracture (6,376 reports)

Browse all side effects of Kaletra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tibia fracture:

Tibia fracture (643 drugs)

Browse all the conditions that are associated with Tibia fracture:

Tibia fracture (670 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lopinavir; ritonavir (the active ingredients of Kaletra) and Kaletra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.