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Keppra and Hypophosphataemia - a phase IV clinical study of FDA data

Summary:

Hypophosphataemia is reported as a side effect among people who take Keppra (levetiracetam), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Vancomycin, and have Pain.

The phase IV clinical study analyzes which people have Hypophosphataemia when taking Keppra. It is created by eHealthMe based on reports of 70,297 people who have side effects when taking Keppra from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Hypophosphataemia?

Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood) is found to be associated with 869 drugs and 782 conditions by eHealthMe. Check the latest studies of Hypophosphataemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

70,297 people reported to have side effects when taking Keppra.
Among them, 44 people (0.06%) have Hypophosphataemia.

Could Keppra cause Hypophosphataemia?

Among these 44 people:

How long have people been on Keppra when they have Hypophosphataemia? *

  • < 1 month: 75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 25 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypophosphataemia when taking Keppra? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Hypophosphataemia when taking Keppra? *

  • 0-1: 4.76 %
  • 2-9: 19.05 %
  • 10-19: 11.9 %
  • 20-29: 2.38 %
  • 30-39: 4.76 %
  • 40-49: 26.19 %
  • 50-59: 9.52 %
  • 60+: 21.43 %

What are other drugs people take besides Keppra? *

  1. Temodar: 8 people, 18.18%
  2. Vancomycin: 8 people, 18.18%
  3. Tramadol Hydrochloride: 7 people, 15.91%
  4. Medrol: 7 people, 15.91%
  5. Capecitabine: 7 people, 15.91%
  6. Spironolactone: 7 people, 15.91%
  7. Synthroid: 6 people, 13.64%
  8. Decadron: 6 people, 13.64%
  9. Ativan: 6 people, 13.64%
  10. Dexamethasone: 6 people, 13.64%

What are other side effects people have besides Hypophosphataemia? *

  1. Hypokalemia (low potassium): 19 people, 43.18%
  2. Diarrhea: 12 people, 27.27%
  3. Fever: 11 people, 25.00%
  4. Thrombocytopenia (decrease of platelets in blood): 11 people, 25.00%
  5. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 10 people, 22.73%
  6. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 9 people, 20.45%
  7. Haemoglobin Decreased: 9 people, 20.45%
  8. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 8 people, 18.18%
  9. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 7 people, 15.91%
  10. Aspartate Aminotransferase Increased: 7 people, 15.91%

What are the existing conditions these people have? *

  1. Pain: 9 people, 20.45%
  2. Diarrhea: 7 people, 15.91%
  3. Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 5 people, 11.36%
  4. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 9.09%
  5. Malignant Glioma (cancerous tumour of brain a cancer tumour of uncertain origin that arises both in soft tissue and bone): 3 people, 6.82%
  6. Cytomegalovirus Infection: 3 people, 6.82%
  7. Nausea (feeling of having an urge to vomit): 3 people, 6.82%
  8. Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 3 people, 6.82%
  9. Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 3 people, 6.82%
  10. Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Keppra and have Hypophosphataemia?

- Check whether Hypophosphataemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keppra:

Hypophosphataemia treatments and more:

How severe was Hypophosphataemia and when was it recovered:

Expand to all the drugs that have ingredients of levetiracetam:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypophosphataemia:

Browse all the conditions that are associated with Hypophosphataemia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Keppra) and Keppra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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