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Keppra and Initial insomnia - a phase IV clinical study of FDA data

Summary:

Initial insomnia is reported as a side effect among people who take Keppra (levetiracetam), especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months also take Tegretol, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Initial insomnia when taking Keppra. It is created by eHealthMe based on reports of 70,297 people who have side effects when taking Keppra from the FDA, and is updated regularly.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 713 drugs and 689 conditions by eHealthMe. Check the latest studies of Initial insomnia.

On Aug, 09, 2026

70,297 people reported to have side effects when taking Keppra.
Among them, 79 people (0.11%) have Initial insomnia.

Could Keppra cause Initial insomnia?

Among these 79 people:

How long have people been on Keppra when they have Initial insomnia? *

  • < 1 month: 23.81 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 76.19 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Initial insomnia when taking Keppra? *

  • female: 60.53 %
  • male: 39.47 %

What is the age of people who have Initial insomnia when taking Keppra? *

  • 0-1: 2.13 %
  • 2-9: 6.38 %
  • 10-19: 2.13 %
  • 20-29: 19.15 %
  • 30-39: 21.28 %
  • 40-49: 38.3 %
  • 50-59: 4.26 %
  • 60+: 6.38 %

What are other drugs people take besides Keppra? *

  1. Tegretol: 16 people, 20.25%
  2. Lamictal: 15 people, 18.99%
  3. Vimpat: 13 people, 16.46%
  4. Lyrica: 11 people, 13.92%
  5. Ferrous Fumarate: 9 people, 11.39%
  6. Topamax: 9 people, 11.39%
  7. Xyrem: 5 people, 6.33%
  8. Tasigna: 5 people, 6.33%
  9. Tizanidine Hydrochloride: 4 people, 5.06%
  10. Pantoprazole Sodium: 4 people, 5.06%

What are other side effects people have besides Initial insomnia? *

  1. Depression: 30 people, 37.97%
  2. Itching: 25 people, 31.65%
  3. Insomnia (sleeplessness): 24 people, 30.38%
  4. Pain: 22 people, 27.85%
  5. Fatigue (feeling of tiredness): 21 people, 26.58%
  6. Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 18 people, 22.78%
  7. Headache (pain in head): 17 people, 21.52%
  8. Stress And Anxiety: 17 people, 21.52%
  9. Weakness: 16 people, 20.25%
  10. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 16 people, 20.25%

What are the existing conditions these people have? *

  1. Immunoglobulins Decreased: 14 people, 17.72%
  2. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 14 people, 17.72%
  3. Restless Leg Syndrome (a powerful urge to move your legs): 10 people, 12.66%
  4. Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 9 people, 11.39%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 7.59%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.33%
  7. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 5 people, 6.33%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 5.06%
  9. Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 4 people, 5.06%
  10. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

Do you take Keppra and have Initial insomnia?

- Check whether Initial insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keppra:

Initial insomnia treatments and more:

How severe was Initial insomnia and when was it recovered:

Expand to all the drugs that have ingredients of levetiracetam:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Initial insomnia:

Browse all the conditions that are associated with Initial insomnia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Keppra) and Keppra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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