Ketoprofen and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Ketoprofen (ketoprofen), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Paracetamol, and have Polyarthritis.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Ketoprofen. It is created by eHealthMe based on reports of 14,955 people who have side effects when taking Ketoprofen from the FDA, and is updated regularly.

What is Ketoprofen?

Ketoprofen has active ingredients of ketoprofen. It is often used in pain. eHealthMe is studying from 15,048 Ketoprofen users. Check the latest studies of Ketoprofen.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,185 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

14,955 people reported to have side effects when taking Ketoprofen.
Among them, 31 people (0.21%) have Acute hepatic failure.

Could Ketoprofen cause Acute hepatic failure?

Among these 31 people:

How long have people been on Ketoprofen when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Ketoprofen? *

female: 17.86 %
male: 82.14 %

What is the age of people who have Acute hepatic failure when taking Ketoprofen? *

What are other drugs people take besides Ketoprofen? *

Paracetamol: 14 people, 45.16%
Solu-Medrol: 7 people, 22.58%
Norvasc: 7 people, 22.58%
Gilenya: 6 people, 19.35%
Dactinomycin: 4 people, 12.90%
Acetaminophen And Codeine Phosphate: 4 people, 12.90%
Diclofenac: 3 people, 9.68%
Ibuprofen: 2 people, 6.45%
Meropenem: 1 person, 3.23%
Meloxicam: 1 person, 3.23%

What are other side effects people have besides Acute hepatic failure? *

Thrombocytopenia (decrease of platelets in blood): 23 people, 74.19%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 16 people, 51.61%
Acute Kidney Failure: 16 people, 51.61%
Leukopenia (less number of white blood cells in blood): 15 people, 48.39%
Anaemia (lack of blood): 15 people, 48.39%
Nausea And Vomiting: 12 people, 38.71%
Diarrhea: 12 people, 38.71%
Ascites (accumulation of fluid in the abdominal cavity): 11 people, 35.48%
Haematemesis (vomiting of blood): 11 people, 35.48%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 11 people, 35.48%

What are the existing conditions these people have? *

Polyarthritis (arthritis which involves 5 or more joints simultaneously): 11 people, 35.48%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 7 people, 22.58%
Insomnia (sleeplessness): 7 people, 22.58%
Back Pain: 7 people, 22.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 16.13%
Rashes (redness): 4 people, 12.90%
Wilms Tumor (cancer of the kidneys that typically occurs in children): 3 people, 9.68%
Skin Ulcer: 3 people, 9.68%
Suicide Attempt: 2 people, 6.45%
Gout (uric acid crystals building up in the body): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Ketoprofen and have Acute hepatic failure?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ketoprofen:

Ketoprofen (15,048 reports)

Browse all side effects of Ketoprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,185 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ketoprofen (the active ingredients of Ketoprofen) and Ketoprofen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.