Keytruda and Orthostatic hypotension - a phase IV clinical study of FDA data

Summary:

Orthostatic hypotension is reported as a side effect among people who take Keytruda (pembrolizumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Carboplatin, and have Lung adenocarcinoma.

The phase IV clinical study analyzes which people have Orthostatic hypotension when taking Keytruda. It is created by eHealthMe based on reports of 57,304 people who have side effects when taking Keytruda from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Orthostatic hypotension?

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up) is found to be associated with 1,232 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Orthostatic hypotension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

57,304 people reported to have side effects when taking Keytruda.
Among them, 34 people (0.06%) have Orthostatic hypotension.

Could Keytruda cause Orthostatic hypotension?

Among these 34 people:

How long have people been on Keytruda when they have Orthostatic hypotension? *

What is the gender of people who have Orthostatic hypotension when taking Keytruda? *

female: 71.88 %
male: 28.12 %

What is the age of people who have Orthostatic hypotension when taking Keytruda? *

What are other drugs people take besides Keytruda? *

What are other side effects people have besides Orthostatic hypotension? *

Malaise (a feeling of general discomfort or uneasiness): 11 people, 32.35%
Rashes (redness): 6 people, 17.65%
Fever: 4 people, 11.76%
Back Pain: 4 people, 11.76%
Hypotension (abnormally low blood pressure): 3 people, 8.82%
Urinary Retention (the inability to completely or partially empty the bladder): 3 people, 8.82%
Dizziness: 3 people, 8.82%
Thrombocytopenia (decrease of platelets in blood): 3 people, 8.82%
Leukocytosis (increased white blood cells): 3 people, 8.82%
Weight Decreased: 3 people, 8.82%

What are the existing conditions these people have? *

Lung Adenocarcinoma (a form of non-small cell lung cancer): 12 people, 35.29%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 8.82%
Endometrial Cancer: 3 people, 8.82%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 3 people, 8.82%
Bone Density Decreased: 2 people, 5.88%
Cardiac Failure Chronic: 2 people, 5.88%
Salivary Gland Atrophy (wasting of salivary gland): 2 people, 5.88%
Osteoporosis (bones weak and more likely to break): 2 people, 5.88%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 5.88%
Hypotension (abnormally low blood pressure): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Keytruda and have Orthostatic hypotension?

- Check whether Orthostatic hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keytruda:

Keytruda (57,404 reports)

Browse all side effects of Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,232 drugs)

Browse all the conditions that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,336 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pembrolizumab (the active ingredients of Keytruda) and Keytruda (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.