Keytruda and Protein urine present - a phase IV clinical study of FDA data

Summary:

Protein urine present is reported as a side effect among people who take Keytruda (pembrolizumab), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lenvima, and have Endometrial cancer.

The phase IV clinical study analyzes which people have Protein urine present when taking Keytruda. It is created by eHealthMe based on reports of 57,304 people who have side effects when taking Keytruda from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

What is Protein urine present?

Protein urine present is found to be associated with 672 drugs and 820 conditions by eHealthMe. Check the latest studies of Protein urine present.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

57,304 people reported to have side effects when taking Keytruda.
Among them, 73 people (0.13%) have Protein urine present.

Could Keytruda cause Protein urine present?

Among these 73 people:

How long have people been on Keytruda when they have Protein urine present? *

What is the gender of people who have Protein urine present when taking Keytruda? *

female: 54.17 %
male: 45.83 %

What is the age of people who have Protein urine present when taking Keytruda? *

What are other drugs people take besides Keytruda? *

What are other side effects people have besides Protein urine present? *

High Blood Pressure: 36 people, 49.32%
Diarrhea: 26 people, 35.62%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 18 people, 24.66%
Malignant Neoplasm Progression (cancer tumour came back): 16 people, 21.92%
Fatigue (feeling of tiredness): 15 people, 20.55%
Thrombocytopenia (decrease of platelets in blood): 14 people, 19.18%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 13 people, 17.81%
Palmar-Plantar Erythrodysaesthesia Syndrome (hand-foot syndrome): 12 people, 16.44%
Haemoglobin Decreased: 11 people, 15.07%
Rashes (redness): 11 people, 15.07%

What are the existing conditions these people have? *

Endometrial Cancer: 26 people, 35.62%
High Blood Pressure: 9 people, 12.33%
Renal Cell Carcinoma Stage Iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes): 6 people, 8.22%
Endometrial Cancer Metastatic: 3 people, 4.11%
Lung Squamous Cell Carcinoma Stage Iii (lung cancer has spread to lymph nodes on the same side of the chest as the tumour. the lymph nodes with cancer are near the sternum (chest bone) or where the bronchus enters the lung): 2 people, 2.74%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 2.74%
Indigestion: 2 people, 2.74%
Transitional Cell Carcinoma (cancer tumour inner most layer of urinary system): 2 people, 2.74%
Cancer Pain: 2 people, 2.74%
Neuropathy Peripheral (surface nerve damage): 2 people, 2.74%

* Approximation only. Some reports may have incomplete information.

Do you take Keytruda and have Protein urine present?

- Check whether Protein urine present is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keytruda:

Keytruda (57,404 reports)

Browse all side effects of Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Protein urine present:

Protein urine present (672 drugs)

Browse all the conditions that are associated with Protein urine present:

Protein urine present (820 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pembrolizumab (the active ingredients of Keytruda) and Keytruda (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.