Keytruda and Ttp - a phase IV clinical study of FDA data

Summary:

Ttp is reported as a side effect among people who take Keytruda (pembrolizumab), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Micardis, and have High blood pressure.

The phase IV clinical study analyzes which people have Ttp when taking Keytruda. It is created by eHealthMe based on reports of 57,304 people who have side effects when taking Keytruda from the FDA, and is updated regularly.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,403 Keytruda users. Check the latest studies of Keytruda.

What is Ttp?

Ttp is found to be associated with 928 drugs and 822 conditions by eHealthMe. Check the latest studies of Ttp.

On Feb, 05, 2026

57,304 people reported to have side effects when taking Keytruda.
Among them, 22 people (0.04%) have Ttp.

Among these 22 people:

How long have people been on Keytruda when they have Ttp? *

What is the gender of people who have Ttp when taking Keytruda? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Ttp when taking Keytruda? *

What are other drugs people take besides Keytruda? *

What are other side effects people have besides Ttp? *

Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 6 people, 27.27%
Thrombocytopenia (decrease of platelets in blood): 6 people, 27.27%
Haemolytic Anaemia (anaemia due to haemolysis): 6 people, 27.27%
Circulatory Collapse: 6 people, 27.27%
Malignant Neoplasm Progression (cancer tumour came back): 5 people, 22.73%
Polymyalgia Rheumatica (pain in many muscles): 3 people, 13.64%
Diarrhea: 3 people, 13.64%
Microangiopathic Haemolytic Anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells): 2 people, 9.09%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 9.09%
Abdominal Distension: 2 people, 9.09%

What are the existing conditions these people have? *

Polymyalgia Rheumatica (pain in many muscles): 6 people, 27.27%
Muscle Spasms (muscle contraction): 6 people, 27.27%
Enlarged Prostate: 6 people, 27.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 27.27%
High Blood Pressure: 6 people, 27.27%
Bladder Transitional Cell Carcinoma (types of bladder cancer): 4 people, 18.18%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 13.64%
Bladder Cancer Stage Iv: 2 people, 9.09%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 9.09%
Renal Cell Carcinoma Stage Iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Keytruda and have Ttp?

- Check whether Ttp is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Keytruda:

Keytruda (57,403 reports)

Ttp treatments and more:

Ttp (6,447 reports)

Browse all side effects of Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ttp:

Ttp (928 drugs)

Browse all the conditions that are associated with Ttp:

Ttp (822 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pembrolizumab (the active ingredients of Keytruda) and Keytruda (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.