Kineret and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Kineret (anakinra), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Ciclosporin, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Kineret. It is created by eHealthMe based on reports of 11,092 people who have side effects when taking Kineret from the FDA, and is updated regularly.

What is Kineret?

Kineret has active ingredients of anakinra. It is often used in rheumatoid arthritis. eHealthMe is studying from 11,120 Kineret users. Check the latest studies of Kineret.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,348 drugs and 1,691 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 04, 2026

11,092 people reported to have side effects when taking Kineret.
Among them, 16 people (0.14%) have Aseptic necrosis.

Among these 16 people:

How long have people been on Kineret when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Kineret? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Aseptic necrosis when taking Kineret? *

What are other drugs people take besides Kineret? *

What are other side effects people have besides Aseptic necrosis? *

Left Ventricular Dysfunction: 7 people, 43.75%
Adenovirus Infection: 7 people, 43.75%
Fasciitis (infection of muscle surrounding tissue): 7 people, 43.75%
Herpes Zoster: 7 people, 43.75%
Drug Ineffective: 6 people, 37.50%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 31.25%
Acute Graft Versus Host Disease In Intestine (acute complication in intestine following an allogeneic tissue/blood transplant): 4 people, 25.00%
Viraemia (presence of a virus in the blood stream): 4 people, 25.00%
Acute Graft Versus Host Disease In Skin (acute complication on skin following an allogeneic tissue/blood transplant): 4 people, 25.00%
Serratia Infection (bacterial infection): 4 people, 25.00%

What are the existing conditions these people have? *

Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 7 people, 43.75%
Bone Marrow Conditioning Regimen: 7 people, 43.75%
Osteoporosis (bones weak and more likely to break): 2 people, 12.50%
Still's Disease Adult Onset (a rare illness that causes high fevers, rash, and joint pain in adult just started): 1 person, 6.25%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 1 person, 6.25%
Monoclonal Gammopathy: 1 person, 6.25%
Immunodeficiency Disorders: 1 person, 6.25%
Histiocytosis Haematophagic: 1 person, 6.25%
Crystal Arthropathy (accumulation of crystals in joints): 1 person, 6.25%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Kineret and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Kineret:

Kineret (11,120 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Kineret:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,348 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,691 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on anakinra (the active ingredients of Kineret) and Kineret (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.