Klonopin and Tension headache - a phase IV clinical study of FDA data

Summary:

Tension headache is reported as a side effect among people who take Klonopin (clonazepam), especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months also take Soma, and have Depression.

The phase IV clinical study analyzes which people have Tension headache when taking Klonopin. It is created by eHealthMe based on reports of 59,526 people who have side effects when taking Klonopin from the FDA, and is updated regularly.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

What is Tension headache?

Tension headache is found to be associated with 542 drugs and 964 conditions by eHealthMe. Check the latest studies of Tension headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

59,526 people reported to have side effects when taking Klonopin.
Among them, 62 people (0.1%) have Tension headache.

Among these 62 people:

How long have people been on Klonopin when they have Tension headache? *

What is the gender of people who have Tension headache when taking Klonopin? *

female: 75.41 %
male: 24.59 %

What is the age of people who have Tension headache when taking Klonopin? *

What are other drugs people take besides Klonopin? *

What are other side effects people have besides Tension headache? *

Depression: 26 people, 41.94%
Pain: 21 people, 33.87%
Memory Loss: 18 people, 29.03%
Insomnia (sleeplessness): 18 people, 29.03%
Fatigue (feeling of tiredness): 17 people, 27.42%
Chest Pain: 16 people, 25.81%
Fall: 16 people, 25.81%
Constipation: 15 people, 24.19%
Joint Pain: 15 people, 24.19%
Malaise (a feeling of general discomfort or uneasiness): 14 people, 22.58%

What are the existing conditions these people have? *

Depression: 16 people, 25.81%
Pain: 11 people, 17.74%
Migraine (headache): 8 people, 12.90%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 9.68%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 8.06%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 8.06%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 5 people, 8.06%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 4 people, 6.45%
Drowsiness: 4 people, 6.45%
Bipolar Disorder (mood disorder): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Klonopin and have Tension headache?

- Check whether Tension headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Klonopin:

Klonopin (65,112 reports)

Browse all side effects of Klonopin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tension headache:

Tension headache (542 drugs)

Browse all the conditions that are associated with Tension headache:

Tension headache (964 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on clonazepam (the active ingredients of Klonopin) and Klonopin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.