Konakion and International normalised ratio increased - a phase IV clinical study of FDA data

Summary:

International normalised ratio increased is reported as a side effect among people who take Konakion (phytonadione), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Rocephin, and have Cardiac failure.

The phase IV clinical study analyzes which people have International normalised ratio increased when taking Konakion. It is created by eHealthMe based on reports of 1,341 people who have side effects when taking Konakion from the FDA, and is updated regularly.

What is Konakion?

Konakion has active ingredients of phytonadione. eHealthMe is studying from 1,342 Konakion users. Check the latest studies of Konakion.

What is International normalised ratio increased?

International normalised ratio increased is found to be associated with 1,338 drugs and 1,726 conditions by eHealthMe. Check the latest studies of International normalised ratio increased.

On Jul, 15, 2026

1,341 people reported to have side effects when taking Konakion.
Among them, 39 people (2.91%) have International normalised ratio increased.

Could Konakion cause International normalised ratio increased?

Among these 39 people:

How long have people been on Konakion when they have International normalised ratio increased? *

What is the gender of people who have International normalised ratio increased when taking Konakion? *

female: 50 %
male: 50 %

What is the age of people who have International normalised ratio increased when taking Konakion? *

What are other drugs people take besides Konakion? *

What are other side effects people have besides International normalised ratio increased? *

Thrombocytopenia (decrease of platelets in blood): 20 people, 51.28%
Pneumonia: 19 people, 48.72%
Acute Kidney Failure: 17 people, 43.59%
Red Blood Cell Count Decreased: 12 people, 30.77%
Pleural Effusion (water on the lungs): 12 people, 30.77%
Staphylococcal Infection (an infection with staphylococcus bacteria): 11 people, 28.21%
Inappropriate Antidiuretic Hormone Secretion: 11 people, 28.21%
Septic Shock (shock due to blood infection): 11 people, 28.21%
High Blood Pressure: 11 people, 28.21%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 10 people, 25.64%

What are the existing conditions these people have? *

Cardiac Failure: 12 people, 30.77%
Multiple Myeloma (cancer of the plasma cells): 11 people, 28.21%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 25.64%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 8 people, 20.51%
Constipation: 6 people, 15.38%
Gastritis (inflammation of stomach): 5 people, 12.82%
Hypokalemia (low potassium): 5 people, 12.82%
Anal Haemorrhage: 3 people, 7.69%
Capillary Disorder (capillary disease): 3 people, 7.69%
Delirium (wild excitement): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Konakion and have International normalised ratio increased?

- Check whether International normalised ratio increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Konakion:

Konakion (1,342 reports)

International normalised ratio increased treatments and more:

International normalised ratio increased (40,071 reports)

How severe was International normalised ratio increased and when was it recovered:

International normalised ratio increased in Konakion

Expand to all the drugs that have ingredients of phytonadione:

International normalised ratio increased and drugs with ingredients of phytonadione

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Konakion:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with International normalised ratio increased:

International normalised ratio increased (1,338 drugs)

Browse all the conditions that are associated with International normalised ratio increased:

International normalised ratio increased (1,726 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on phytonadione (the active ingredients of Konakion) and Konakion (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.