L-lysine and High blood cholesterol - a phase IV clinical study of FDA data

Summary:

High blood cholesterol is reported as a side effect among people who take L-lysine (lysine), especially for people who are female, 60+ old, also take Folic Acid, and have Indigestion.

The phase IV clinical study analyzes which people have High blood cholesterol when taking L-lysine. It is created by eHealthMe based on reports of 1,219 people who have side effects when taking L-lysine from the FDA, and is updated regularly.

What is L-lysine?

L-lysine has active ingredients of lysine. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 1,560 L-lysine users. Check the latest studies of L-lysine.

What is High blood cholesterol?

High blood cholesterol is found to be associated with 2,284 drugs and 3,556 conditions by eHealthMe. Check the latest studies of High blood cholesterol.

On Apr, 05, 2026

1,219 people reported to have side effects when taking L-lysine.
Among them, 23 people (1.89%) have High blood cholesterol.

Could L-lysine cause High blood cholesterol?

Among these 23 people:

What is the gender of people who have High blood cholesterol when taking L-lysine? *

female: 91.3 %
male: 8.7 %

What is the age of people who have High blood cholesterol when taking L-lysine? *

What are other drugs people take besides L-lysine? *

Zestril: 7 people, 30.43%
Remicade: 7 people, 30.43%
Pantoprazole: 7 people, 30.43%
Orencia: 7 people, 30.43%
Minocycline Hydrochloride: 7 people, 30.43%
Methotrexate: 7 people, 30.43%
Kevzara: 7 people, 30.43%
Hydroxychloroquine Sulfate: 7 people, 30.43%
Humira: 7 people, 30.43%
Folic Acid: 7 people, 30.43%

What are other side effects people have besides High blood cholesterol? *

High Blood Pressure: 10 people, 43.48%
Fatigue (feeling of tiredness): 10 people, 43.48%
Drug Ineffective: 9 people, 39.13%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 8 people, 34.78%
Joint Pain: 8 people, 34.78%
Hair Loss: 8 people, 34.78%
Headache (pain in head): 8 people, 34.78%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 7 people, 30.43%
Mobility Decreased (ability to move is reduced): 7 people, 30.43%
Infusion Related Reaction: 7 people, 30.43%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 30.43%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 30.43%
Indigestion: 7 people, 30.43%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 3 people, 13.04%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.04%
High Blood Pressure: 2 people, 8.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.70%
Drowsiness: 2 people, 8.70%
Fatigue (feeling of tiredness): 2 people, 8.70%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take L-lysine and have High blood cholesterol?

- Check whether High blood cholesterol is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to L-lysine:

L-lysine (1,560 reports)

Browse all side effects of L-lysine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with High blood cholesterol:

High blood cholesterol (2,284 drugs)

Browse all the conditions that are associated with High blood cholesterol:

High blood cholesterol (3,556 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lysine (the active ingredients of L-lysine) and L-lysine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.