Lacosamide and Cholestasis - a phase IV clinical study of FDA data

Summary:

Cholestasis is reported as a side effect among people who take Lacosamide (lacosamide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Bosulif, and have Meningioma.

The phase IV clinical study analyzes which people have Cholestasis when taking Lacosamide. It is created by eHealthMe based on reports of 16,542 people who have side effects when taking Lacosamide from the FDA, and is updated regularly.

What is Lacosamide?

Lacosamide has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 16,601 Lacosamide users. Check the latest studies of Lacosamide.

What is Cholestasis?

Cholestasis (a condition where bile cannot flow from the liver to the duodenum) is found to be associated with 1,032 drugs and 1,814 conditions by eHealthMe. Check the latest studies of Cholestasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

16,542 people reported to have side effects when taking Lacosamide.
Among them, 41 people (0.25%) have Cholestasis.

Among these 41 people:

How long have people been on Lacosamide when they have Cholestasis? *

What is the gender of people who have Cholestasis when taking Lacosamide? *

female: 47.22 %
male: 52.78 %

What is the age of people who have Cholestasis when taking Lacosamide? *

What are other drugs people take besides Lacosamide? *

Pantoprazole: 7 people, 17.07%
Trileptal: 7 people, 17.07%
Bosulif: 7 people, 17.07%
Bactrim: 6 people, 14.63%
Escitalopram: 6 people, 14.63%
Lansoprazole: 3 people, 7.32%
Keppra: 3 people, 7.32%
Acetylsalicylate Lysine: 3 people, 7.32%
Tacrolimus: 3 people, 7.32%
Lovenox: 2 people, 4.88%

What are other side effects people have besides Cholestasis? *

Hepatocellular Injury (liver injury): 16 people, 39.02%
Liver Disorder (liver diseases): 10 people, 24.39%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 7 people, 17.07%
Dizziness: 7 people, 17.07%
Weakness: 6 people, 14.63%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 4 people, 9.76%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 4 people, 9.76%
Thrombocytopenia (decrease of platelets in blood): 3 people, 7.32%
Fibroma (tumours that are composed of fibrous or connective tissue): 3 people, 7.32%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 2 people, 4.88%

What are the existing conditions these people have? *

Meningioma (a diverse set of tumours arising from the meninges): 10 people, 24.39%
Diarrhea: 7 people, 17.07%
Nausea And Vomiting: 7 people, 17.07%
Nausea (feeling of having an urge to vomit): 7 people, 17.07%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 7 people, 17.07%
High Blood Pressure: 4 people, 9.76%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 7.32%
Thrombotic Stroke (stroke due to clot formation): 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 4.88%

* Approximation only. Some reports may have incomplete information.

Do you take Lacosamide and have Cholestasis?

- Check whether Cholestasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lacosamide:

Lacosamide (16,601 reports)

Cholestasis treatments and more:

Cholestasis (23,731 reports)

Browse all side effects of Lacosamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cholestasis:

Cholestasis (1,032 drugs)

Browse all the conditions that are associated with Cholestasis:

Cholestasis (1,814 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lacosamide (the active ingredients of Lacosamide) and Lacosamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.