Lacosamide and Hyperammonaemia - a phase IV clinical study of FDA data

Summary:

Hyperammonaemia is reported as a side effect among people who take Lacosamide (lacosamide), especially for people who are female, 2-9 old, have been taking the drug for < 1 month also take Perampanel, and have Status epilepticus.

The phase IV clinical study analyzes which people have Hyperammonaemia when taking Lacosamide. It is created by eHealthMe based on reports of 16,542 people who have side effects when taking Lacosamide from the FDA, and is updated regularly.

What is Lacosamide?

Lacosamide has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 16,601 Lacosamide users. Check the latest studies of Lacosamide.

What is Hyperammonaemia?

Hyperammonaemia is found to be associated with 404 drugs and 559 conditions by eHealthMe. Check the latest studies of Hyperammonaemia.

On Jul, 12, 2026

16,542 people reported to have side effects when taking Lacosamide.
Among them, 76 people (0.46%) have Hyperammonaemia.

Among these 76 people:

How long have people been on Lacosamide when they have Hyperammonaemia? *

What is the gender of people who have Hyperammonaemia when taking Lacosamide? *

female: 50.88 %
male: 49.12 %

What is the age of people who have Hyperammonaemia when taking Lacosamide? *

What are other drugs people take besides Lacosamide? *

What are other side effects people have besides Hyperammonaemia? *

Encephalopathy (functioning of the brain is affected by some agent or condition): 14 people, 18.42%
Drug Ineffective: 14 people, 18.42%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 13 people, 17.11%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 10 people, 13.16%
Consciousness - Decreased: 8 people, 10.53%
Hepatic Enzyme Increased: 8 people, 10.53%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 10.53%
Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 7 people, 9.21%
Ureaplasma Infection: 6 people, 7.89%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 7.89%

What are the existing conditions these people have? *

Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 16 people, 21.05%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 10 people, 13.16%
Partial Seizures (seizures which affect only a part of the brain at onset): 5 people, 6.58%
Cardiac Disorder: 4 people, 5.26%
Interstitial Lung Disease: 3 people, 3.95%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 2 people, 2.63%
Partial Seizures With Secondary Generalisation (partial seizure may spread within the brain, a process known as secondary generalization): 1 person, 1.32%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 1 person, 1.32%
Immunodeficiency Disorders: 1 person, 1.32%
General Anaesthesia: 1 person, 1.32%

* Approximation only. Some reports may have incomplete information.

Do you take Lacosamide and have Hyperammonaemia?

- Check whether Hyperammonaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lacosamide:

Lacosamide (16,601 reports)

Hyperammonaemia treatments and more:

Hyperammonaemia (6,053 reports)

Browse all side effects of Lacosamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperammonaemia:

Hyperammonaemia (404 drugs)

Browse all the conditions that are associated with Hyperammonaemia:

Hyperammonaemia (559 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lacosamide (the active ingredients of Lacosamide) and Lacosamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.