Lamotrigine and Atrioventricular block first degree - a phase IV clinical study of FDA data

Summary:

Atrioventricular block first degree is reported as a side effect among people who take Lamotrigine (lamotrigine), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lacosamide, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Atrioventricular block first degree when taking Lamotrigine. It is created by eHealthMe based on reports of 72,834 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Atrioventricular block first degree?

Atrioventricular block first degree (heart block first degree) is found to be associated with 646 drugs and 890 conditions by eHealthMe. Check the latest studies of Atrioventricular block first degree.

On Aug, 09, 2026

72,834 people reported to have side effects when taking Lamotrigine.
Among them, 43 people (0.06%) have Atrioventricular block first degree.

Could Lamotrigine cause Atrioventricular block first degree?

Among these 43 people:

How long have people been on Lamotrigine when they have Atrioventricular block first degree? *

What is the gender of people who have Atrioventricular block first degree when taking Lamotrigine? *

female: 44.12 %
male: 55.88 %

What is the age of people who have Atrioventricular block first degree when taking Lamotrigine? *

What are other drugs people take besides Lamotrigine? *

What are other side effects people have besides Atrioventricular block first degree? *

Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 12 people, 27.91%
Electrocardiogram Abnormal: 12 people, 27.91%
Suicide Attempt: 9 people, 20.93%
Fatigue (feeling of tiredness): 8 people, 18.60%
Overdose: 7 people, 16.28%
Chest Pain: 5 people, 11.63%
Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 5 people, 11.63%
Electrocardiogram Qrs Complex Prolonged: 5 people, 11.63%
Fever: 5 people, 11.63%
White Blood Cell Count Increased: 4 people, 9.30%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 11.63%
Partial Seizures (seizures which affect only a part of the brain at onset): 4 people, 9.30%
High Blood Pressure: 4 people, 9.30%
High Blood Cholesterol: 4 people, 9.30%
Suicide Attempt: 2 people, 4.65%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 4.65%
Complex Partial Seizures (epileptic seizure): 2 people, 4.65%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 4.65%
Depression: 2 people, 4.65%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and have Atrioventricular block first degree?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamotrigine:

Lamotrigine (76,638 reports)

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Atrioventricular block first degree:

Atrioventricular block first degree (646 drugs)

Browse all the conditions that are associated with Atrioventricular block first degree:

Atrioventricular block first degree (890 conditions)

Related publications that referenced our studies

Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamotrigine) and Lamotrigine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.