Lamotrigine and Clonic convulsion - a phase IV clinical study of FDA data

Summary:

Clonic convulsion is reported as a side effect among people who take Lamotrigine (lamotrigine), especially for people who are female, 10-19 old, also take Valproic Acid, and have Convulsions local.

The phase IV clinical study analyzes which people have Clonic convulsion when taking Lamotrigine. It is created by eHealthMe based on reports of 72,834 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,639 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Clonic convulsion?

Clonic convulsion (long lasting seizure) is found to be associated with 135 drugs and 305 conditions by eHealthMe. Check the latest studies of Clonic convulsion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

72,834 people reported to have side effects when taking Lamotrigine.
Among them, 25 people (0.03%) have Clonic convulsion.

Could Lamotrigine cause Clonic convulsion?

Among these 25 people:

What is the gender of people who have Clonic convulsion when taking Lamotrigine? *

female: 54.17 %
male: 45.83 %

What is the age of people who have Clonic convulsion when taking Lamotrigine? *

What are other drugs people take besides Lamotrigine? *

What are other side effects people have besides Clonic convulsion? *

Drug Ineffective: 6 people, 24.00%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 24.00%
Overdose: 6 people, 24.00%
Fall: 4 people, 16.00%
Mental Retardation (problems with learning and developing): 4 people, 16.00%
Multiple-Drug Resistance: 4 people, 16.00%
Femur Fracture: 4 people, 16.00%
Petit Mal Epilepsy (absence seizure): 4 people, 16.00%
Postictal State: 2 people, 8.00%
Hyperreflexia (overactive or over responsive reflexes): 2 people, 8.00%

What are the existing conditions these people have? *

Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 8.00%
Convulsions Local (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly in one of the body parts): 2 people, 8.00%
Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 1 person, 4.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 4.00%
Infantile Spasms: 1 person, 4.00%
Encephalopathy (functioning of the brain is affected by some agent or condition): 1 person, 4.00%
Depression: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and have Clonic convulsion?

- Check whether Clonic convulsion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamotrigine:

Lamotrigine (76,639 reports)

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clonic convulsion:

Clonic convulsion (135 drugs)

Browse all the conditions that are associated with Clonic convulsion:

Clonic convulsion (305 conditions)

Related publications that referenced our studies

Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamotrigine) and Lamotrigine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.