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Lamotrigine and Executive dysfunction - a phase IV clinical study of FDA data

Summary:

Executive dysfunction is reported as a side effect among people who take Lamotrigine (lamotrigine), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Valproate Sodium, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Executive dysfunction when taking Lamotrigine. It is created by eHealthMe based on reports of 72,834 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Executive dysfunction?

Executive dysfunction is found to be associated with 44 drugs and 132 conditions by eHealthMe. Check the latest studies of Executive dysfunction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

72,834 people reported to have side effects when taking Lamotrigine.
Among them, 14 people (0.02%) have Executive dysfunction.

Could Lamotrigine cause Executive dysfunction?

Among these 14 people:

How long have people been on Lamotrigine when they have Executive dysfunction? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 75 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Executive dysfunction when taking Lamotrigine? *

  • female: 27.27 %
  • male: 72.73 %

What is the age of people who have Executive dysfunction when taking Lamotrigine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 40 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 60 %

What are other drugs people take besides Lamotrigine? *

  1. Folic Acid: 3 people, 21.43%
  2. Valproate Sodium: 3 people, 21.43%
  3. Elavil: 2 people, 14.29%
  4. Gilenya: 2 people, 14.29%
  5. Hydromorphone Hydrochloride: 2 people, 14.29%
  6. Imitrex: 2 people, 14.29%
  7. Lyrica: 2 people, 14.29%
  8. Nexium: 2 people, 14.29%
  9. Albuterol: 2 people, 14.29%
  10. Prednisone: 2 people, 14.29%

What are other side effects people have besides Executive dysfunction? *

  1. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 7 people, 50.00%
  2. Nausea And Vomiting: 6 people, 42.86%
  3. Learning Disorder (the brain's disability to receive, process, store, respond to and communicate information): 6 people, 42.86%
  4. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 6 people, 42.86%
  5. Premature Baby: 6 people, 42.86%
  6. Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 6 people, 42.86%
  7. Gait Disturbance: 5 people, 35.71%
  8. Dysgraphia (impaired ability to learn to write): 5 people, 35.71%
  9. Psychomotor Skills Impaired: 5 people, 35.71%
  10. Fever: 4 people, 28.57%

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
  2. Headache (pain in head): 2 people, 14.29%
  3. Depression: 2 people, 14.29%
  4. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 14.29%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 14.29%
  6. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 7.14%
  7. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and have Executive dysfunction?

- Check whether Executive dysfunction is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamotrigine:

Executive dysfunction treatments and more:

How severe was Executive dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of lamotrigine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Executive dysfunction:

Browse all the conditions that are associated with Executive dysfunction:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamotrigine) and Lamotrigine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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