Lantus and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Lantus (insulin glargine recombinant), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Humalog, and have Pain.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Lantus. It is created by eHealthMe based on reports of 190,478 people who have side effects when taking Lantus from the FDA, and is updated regularly.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 493 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

190,478 people reported to have side effects when taking Lantus.
Among them, 24 people (0.01%) have Systemic sclerosis (scleroderma).

Could Lantus cause Systemic sclerosis (scleroderma)?

Among these 24 people:

How long have people been on Lantus when they have Systemic sclerosis (scleroderma)? *

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Lantus? *

female: 79.17 %
male: 20.83 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Lantus? *

What are other drugs people take besides Lantus? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Blood Glucose Increased: 4 people, 16.67%
Mobility Decreased (ability to move is reduced): 3 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 12.50%
Road Traffic Accident: 3 people, 12.50%
Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 3 people, 12.50%
Weight Decreased: 2 people, 8.33%
Oedema Peripheral (superficial swelling): 2 people, 8.33%
Discomfort: 2 people, 8.33%
Dyspnea (difficult or laboured breathing): 2 people, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.33%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 20.83%
Depression: 5 people, 20.83%
Pain: 5 people, 20.83%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 12.50%
High Blood Pressure: 3 people, 12.50%
Weakness: 2 people, 8.33%
Acute Kidney Failure: 2 people, 8.33%
Adrenal Mass: 2 people, 8.33%
Anaemia (lack of blood): 2 people, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lantus and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lantus:

Lantus (191,782 reports)

Browse all side effects of Lantus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (493 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on insulin glargine recombinant (the active ingredients of Lantus) and Lantus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.