Lariam and Mitral valve calcification - a phase IV clinical study of FDA data

Summary:

Mitral valve calcification is reported as a side effect among people who take Lariam (mefloquine hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for 6 - 12 months also take Primaquine,.

The phase IV clinical study analyzes which people have Mitral valve calcification when taking Lariam. It is created by eHealthMe based on reports of 3,078 people who have side effects when taking Lariam from the FDA, and is updated regularly.

What is Lariam?

Lariam has active ingredients of mefloquine hydrochloride. It is often used in malaria. eHealthMe is studying from 3,145 Lariam users. Check the latest studies of Lariam.

What is Mitral valve calcification?

Mitral valve calcification (calcium deposit in mitral valve) is found to be associated with 332 drugs and 293 conditions by eHealthMe. Check the latest studies of Mitral valve calcification.

On Jul, 30, 2026

3,078 people reported to have side effects when taking Lariam.
Among them, 21 people (0.68%) have Mitral valve calcification.

Could Lariam cause Mitral valve calcification?

Among these 21 people:

How long have people been on Lariam when they have Mitral valve calcification? *

What is the gender of people who have Mitral valve calcification when taking Lariam? *

female: 0.0 %
male: 100 %

What is the age of people who have Mitral valve calcification when taking Lariam? *

What are other drugs people take besides Lariam? *

Primaquine: 21 people, 100.00%
Cipro: 17 people, 80.95%

What are other side effects people have besides Mitral valve calcification? *

Humerus Fracture (injury to the upper arm bone): 21 people, 100.00%
Mood Swings (an extreme or rapid change in mood): 21 people, 100.00%
Dysthymia (mild chronic depression): 21 people, 100.00%
Post-Traumatic Stress Disorder: 21 people, 100.00%
Eosinophilia (eosinophil count in the peripheral blood exceeds): 21 people, 100.00%
Exostosis (formation of new bone on the surface of a bone): 21 people, 100.00%
Panic Disorder: 21 people, 100.00%
Fall: 21 people, 100.00%
Fatigue (feeling of tiredness): 21 people, 100.00%
Muscle Aches (muscle pain): 21 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Lariam and have Mitral valve calcification?

- Check whether Mitral valve calcification is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lariam:

Lariam (3,145 reports)

Browse all side effects of Lariam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve calcification:

Mitral valve calcification (332 drugs)

Browse all the conditions that are associated with Mitral valve calcification:

Mitral valve calcification (293 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on mefloquine hydrochloride (the active ingredients of Lariam) and Lariam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.