Leflunomide and Completed suicide - a phase IV clinical study of FDA data

Summary:

Completed suicide is reported as a side effect among people who take Leflunomide (leflunomide), especially for people who are female, 50-59 old, also take Escitalopram, and have Pain.

The study is created by eHealthMe based on reports of 81,713 people who have side effects when taking Leflunomide from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 17, 2026

81,713 people reported to have side effects when taking Leflunomide.
Among them, 18 people (0.02%) died.

Could Leflunomide cause Completed suicide?

Among these 18 people:

What is the gender of people who died when taking Leflunomide? *

female: 100 %
male: 0.0 %

What is the age of people who died when taking Leflunomide? *

What are other drugs people take besides Leflunomide? *

Escitalopram: 15 people, 83.33%
Pamelor: 2 people, 11.11%
Enbrel: 2 people, 11.11%
Anafranil: 2 people, 11.11%
Tivorbex: 1 person, 5.56%
Methotrexate: 1 person, 5.56%
Lyrica: 1 person, 5.56%
Ibuprofen: 1 person, 5.56%
Desvenlafaxine Succinate: 1 person, 5.56%
Cosentyx: 1 person, 5.56%

What are other side effects people have before they died? *

Weight Decreased: 1 person, 5.56%
Transaminases Increased: 1 person, 5.56%
C-Reactive Protein Increased: 1 person, 5.56%
Calcium Deficiency (lack of calcium): 1 person, 5.56%
Drug Intolerance (drug sensitivity): 1 person, 5.56%
Gastrointestinal Sounds Abnormal: 1 person, 5.56%
General Physical Health Deterioration (weak health status): 1 person, 5.56%
Hypokinesia (decreased bodily movement): 1 person, 5.56%
Hypotension (abnormally low blood pressure): 1 person, 5.56%
Hypoxic-Ischaemic Encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total): 1 person, 5.56%

What are the existing conditions these people have? *

Suicide Attempt: 1 person, 5.56%
Skin Cancer: 1 person, 5.56%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.56%
Pain: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leflunomide:

Leflunomide (82,105 reports)

Expand to all the drugs that have ingredients of leflunomide:

Completed suicide and drugs with ingredients of leflunomide (28 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Completed suicide:

Completed suicide (968 drugs)

Browse all the conditions that are associated with Completed suicide:

Completed suicide (1,026 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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