Leflunomide and Cryptococcosis - a phase IV clinical study of FDA data

Summary:

Cryptococcosis is reported as a side effect among people who take Leflunomide (leflunomide), especially for people who are male, 60+ old, also take Methotrexate, and have Cardiac sarcoidosis.

The phase IV clinical study analyzes which people have Cryptococcosis when taking Leflunomide. It is created by eHealthMe based on reports of 81,713 people who have side effects when taking Leflunomide from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Cryptococcosis?

Cryptococcosis (potentially fatal fungal disease) is found to be associated with 149 drugs and 222 conditions by eHealthMe. Check the latest studies of Cryptococcosis.

On Jul, 27, 2026

81,713 people reported to have side effects when taking Leflunomide.
Among them, 15 people (0.02%) have Cryptococcosis.

Among these 15 people:

What is the gender of people who have Cryptococcosis when taking Leflunomide? *

female: 36.36 %
male: 63.64 %

What is the age of people who have Cryptococcosis when taking Leflunomide? *

What are other drugs people take besides Leflunomide? *

What are other side effects people have besides Cryptococcosis? *

Hypotension (abnormally low blood pressure): 6 people, 40.00%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 5 people, 33.33%
Staphylococcal Infection (an infection with staphylococcus bacteria): 5 people, 33.33%
Septic Shock (shock due to blood infection): 5 people, 33.33%
Anuria (failure of the kidneys to produce urine): 5 people, 33.33%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 5 people, 33.33%
Blood Lactic Acid Increased: 5 people, 33.33%
Cardiogenic Shock (inadequate circulation of blood): 5 people, 33.33%
Fatigue (feeling of tiredness): 5 people, 33.33%
General Physical Health Deterioration (weak health status): 5 people, 33.33%

What are the existing conditions these people have? *

Cardiac Sarcoidosis (an immune disorder): 6 people, 40.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 13.33%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and have Cryptococcosis?

- Check whether Cryptococcosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leflunomide:

Leflunomide (82,105 reports)

Cryptococcosis treatments and more:

Cryptococcosis (2,314 reports)

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cryptococcosis:

Cryptococcosis (149 drugs)

Browse all the conditions that are associated with Cryptococcosis:

Cryptococcosis (222 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.