Leflunomide and Kidney fibrosis - a phase IV clinical study of FDA data

Summary:

Kidney fibrosis is reported as a side effect among people who take Leflunomide (leflunomide), especially for people who are female, 40-49 old, also take Actemra, and have Transplant rejection.

The phase IV clinical study analyzes which people have Kidney fibrosis when taking Leflunomide. It is created by eHealthMe based on reports of 81,713 people who have side effects when taking Leflunomide from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Kidney fibrosis?

Kidney fibrosis (excess fibrous connective tissue in kidney) is found to be associated with 192 drugs and 362 conditions by eHealthMe. Check the latest studies of Kidney fibrosis.

On Jul, 08, 2026

81,713 people reported to have side effects when taking Leflunomide.
Among them, 26 people (0.03%) have Kidney fibrosis.

Could Leflunomide cause Kidney fibrosis?

Among these 26 people:

What is the gender of people who have Kidney fibrosis when taking Leflunomide? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Kidney fibrosis when taking Leflunomide? *

What are other drugs people take besides Leflunomide? *

Pantoprazole: 18 people, 69.23%
Actemra: 18 people, 69.23%
Lipitor: 17 people, 65.38%
Acetaminophen: 16 people, 61.54%
Entecavir: 16 people, 61.54%
Tacrolimus: 16 people, 61.54%
Mycophenolate Mofetil: 16 people, 61.54%
Calcitriol: 16 people, 61.54%
Prednisone: 16 people, 61.54%
Amlodipine Besylate: 15 people, 57.69%

What are other side effects people have besides Kidney fibrosis? *

Polyomavirus-Associated Nephropathy (polyomavirus-associated kidney disease): 19 people, 73.08%
Renal Tubular Atrophy (wasting of kidney tubules): 18 people, 69.23%
Haemoglobin Decreased: 18 people, 69.23%
White Blood Cell Count Increased: 17 people, 65.38%
Hyperkalemia (damage to or disease of the kidney): 17 people, 65.38%
Glomerular Filtration Rate Decreased: 17 people, 65.38%
Urine Protein/creatinine Ratio Increased: 17 people, 65.38%
Urine Albumin/creatinine Ratio Increased: 17 people, 65.38%
Lymphocyte Count Decreased: 17 people, 65.38%
Mean Cell Haemoglobin Concentration Decreased (less concentration of haemoglobin in a given volume of packed red blood cells): 17 people, 65.38%

What are the existing conditions these people have? *

Transplant Rejection (a transplant material is not worked): 17 people, 65.38%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 3 people, 11.54%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 3 people, 11.54%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 3.85%
Pain In Extremity: 1 person, 3.85%
Hypercoagulation (increased tendency for clotting of the blood): 1 person, 3.85%
High Blood Pressure: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and have Kidney fibrosis?

- Check whether Kidney fibrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leflunomide:

Leflunomide (82,105 reports)

Kidney fibrosis treatments and more:

Kidney fibrosis (1,874 reports)

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Kidney fibrosis:

Kidney fibrosis (192 drugs)

Browse all the conditions that are associated with Kidney fibrosis:

Kidney fibrosis (362 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.