Leflunomide and Thyroid mass - a phase IV clinical study of FDA data

Summary:

Thyroid mass is reported as a side effect among people who take Leflunomide (leflunomide), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Pantoprazole, and have Osteoporosis.

The phase IV clinical study analyzes which people have Thyroid mass when taking Leflunomide. It is created by eHealthMe based on reports of 81,713 people who have side effects when taking Leflunomide from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Thyroid mass?

Thyroid mass is found to be associated with 489 drugs and 407 conditions by eHealthMe. Check the latest studies of Thyroid mass.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

81,713 people reported to have side effects when taking Leflunomide.
Among them, 44 people (0.05%) have Thyroid mass.

Among these 44 people:

How long have people been on Leflunomide when they have Thyroid mass? *

What is the gender of people who have Thyroid mass when taking Leflunomide? *

female: 88.57 %
male: 11.43 %

What is the age of people who have Thyroid mass when taking Leflunomide? *

What are other drugs people take besides Leflunomide? *

What are other side effects people have besides Thyroid mass? *

High Blood Pressure: 21 people, 47.73%
Urinary Tract Infection: 16 people, 36.36%
Peripheral Swelling: 15 people, 34.09%
Fatigue (feeling of tiredness): 13 people, 29.55%
Weight Increased: 11 people, 25.00%
Joint Pain: 10 people, 22.73%
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood): 9 people, 20.45%
Red Cell Distribution Width Increased: 9 people, 20.45%
Blood Pressure Fluctuation: 9 people, 20.45%
Cyst (a closed sac): 9 people, 20.45%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 20.45%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 9.09%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 3 people, 6.82%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 4.55%
Peripheral Swelling: 2 people, 4.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 4.55%
Eye Swelling: 2 people, 4.55%
Hair Loss: 1 person, 2.27%
Asthma: 1 person, 2.27%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and have Thyroid mass?

- Check whether Thyroid mass is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leflunomide:

Leflunomide (82,105 reports)

Thyroid mass treatments and more:

Thyroid mass (4,811 reports)

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thyroid mass:

Thyroid mass (489 drugs)

Browse all the conditions that are associated with Thyroid mass:

Thyroid mass (407 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide (the active ingredients of Leflunomide) and Leflunomide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.