Letrozole and Atrioventricular block - a phase IV clinical study of FDA data

Summary:

Atrioventricular block is reported as a side effect among people who take Letrozole (letrozole), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Taxol, and have Breast cancer recurrent.

The phase IV clinical study analyzes which people have Atrioventricular block when taking Letrozole. It is created by eHealthMe based on reports of 53,470 people who have side effects when taking Letrozole from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Atrioventricular block?

Atrioventricular block (heart block) is found to be associated with 746 drugs and 876 conditions by eHealthMe. Check the latest studies of Atrioventricular block.

On Jul, 09, 2026

53,470 people reported to have side effects when taking Letrozole.
Among them, 17 people (0.03%) have Atrioventricular block.

Could Letrozole cause Atrioventricular block?

Among these 17 people:

How long have people been on Letrozole when they have Atrioventricular block? *

What is the gender of people who have Atrioventricular block when taking Letrozole? *

female: 100 %
male: 0.0 %

What is the age of people who have Atrioventricular block when taking Letrozole? *

What are other drugs people take besides Letrozole? *

Taxol: 7 people, 41.18%
Ibrance: 6 people, 35.29%
Cyclophosphamide: 3 people, 17.65%
Exemestane: 2 people, 11.76%
Fulvestrant: 1 person, 5.88%
Advil: 1 person, 5.88%
Carboplatin: 1 person, 5.88%
Docetaxel: 1 person, 5.88%
Epirubicin Hydrochloride: 1 person, 5.88%
Famotidine: 1 person, 5.88%

What are other side effects people have besides Atrioventricular block? *

Arteriosclerosis Coronary Artery (thickening and hardening of arteries- coronary artery): 8 people, 47.06%
Hepatic Steatosis (fatty liver disease): 7 people, 41.18%
Nausea And Vomiting: 7 people, 41.18%
Dyspnea (difficult or laboured breathing): 7 people, 41.18%
Chest Pain: 7 people, 41.18%
Cardiogenic Shock (inadequate circulation of blood): 7 people, 41.18%
Hypotension (abnormally low blood pressure): 7 people, 41.18%
C-Reactive Protein Increased: 7 people, 41.18%
Joint Pain: 7 people, 41.18%
Laryngeal Oedema (swelling of larynx): 7 people, 41.18%

What are the existing conditions these people have? *

Breast Cancer Recurrent: 7 people, 41.18%
Breast Cancer Female: 6 people, 35.29%
Malignant Nipple Neoplasm Female (cancer tumour of female nipple): 2 people, 11.76%
Muscle Spasms (muscle contraction): 1 person, 5.88%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and have Atrioventricular block?

- Check whether Atrioventricular block is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letrozole:

Letrozole (54,125 reports)

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Atrioventricular block:

Atrioventricular block (746 drugs)

Browse all the conditions that are associated with Atrioventricular block:

Atrioventricular block (876 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Letrozole) and Letrozole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.