Letrozole and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Letrozole (letrozole), especially for people who are female, 30-39 old, also take Taxol, and have Vitiligo.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Letrozole. It is created by eHealthMe based on reports of 53,470 people who have side effects when taking Letrozole from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 778 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

53,470 people reported to have side effects when taking Letrozole.
Among them, 15 people (0.03%) have Hyperkeratosis.

Among these 15 people:

What is the gender of people who have Hyperkeratosis when taking Letrozole? *

female: 100 %
male: 0.0 %

What is the age of people who have Hyperkeratosis when taking Letrozole? *

What are other drugs people take besides Letrozole? *

Zofran: 8 people, 53.33%
Taxol: 8 people, 53.33%
Acetaminophen And Hydrocodone Bitartrate: 7 people, 46.67%
Nexium: 7 people, 46.67%
Elidel: 7 people, 46.67%
Cytoxan: 7 people, 46.67%
Cyclophosphamide: 7 people, 46.67%
Herceptin: 7 people, 46.67%
Kenalog: 7 people, 46.67%
Kytril: 7 people, 46.67%

What are other side effects people have besides Hyperkeratosis? *

Rashes (redness): 9 people, 60.00%
Joint Stiffness: 9 people, 60.00%
Hypersensitivity: 8 people, 53.33%
Skin Discoloration: 8 people, 53.33%
Skin Papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections): 8 people, 53.33%
Ovarian Cysts (fluid filled sacs of the ovary): 8 people, 53.33%
Weight Increased: 8 people, 53.33%
Intervertebral Disc Protrusion (spinal disc protrusion): 7 people, 46.67%
Eye Swelling: 7 people, 46.67%
Vulvovaginal Dryness: 7 people, 46.67%

What are the existing conditions these people have? *

Vitiligo (pigment is lost from areas of the skin): 7 people, 46.67%
Ovarian Cancer (cancer of ovary): 2 people, 13.33%
The Flu (the flu is caused by an influenza virus): 1 person, 6.67%
Renal Cell Carcinoma (a kidney cancer): 1 person, 6.67%
Metastases To Pleura (cancer spreads to pleura): 1 person, 6.67%
Metastases To Bone (cancer spreads to bone): 1 person, 6.67%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Genital Neoplasm Malignant Female (female genital tract cancer): 1 person, 6.67%
Endometrial Cancer: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letrozole:

Letrozole (54,125 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (778 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Letrozole) and Letrozole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.