Letrozole and Sinus bradycardia - a phase IV clinical study of FDA data

Summary:

Sinus bradycardia is reported as a side effect among people who take Letrozole (letrozole), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Kisqali, and have Arrhythmia supraventricular.

The phase IV clinical study analyzes which people have Sinus bradycardia when taking Letrozole. It is created by eHealthMe based on reports of 53,470 people who have side effects when taking Letrozole from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Sinus bradycardia?

Sinus bradycardia (an unusually slow heartbeat due to heart disease) is found to be associated with 901 drugs and 1,055 conditions by eHealthMe. Check the latest studies of Sinus bradycardia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

53,470 people reported to have side effects when taking Letrozole.
Among them, 47 people (0.09%) have Sinus bradycardia.

Could Letrozole cause Sinus bradycardia?

Among these 47 people:

How long have people been on Letrozole when they have Sinus bradycardia? *

What is the gender of people who have Sinus bradycardia when taking Letrozole? *

female: 100 %
male: 0.0 %

What is the age of people who have Sinus bradycardia when taking Letrozole? *

What are other drugs people take besides Letrozole? *

What are other side effects people have besides Sinus bradycardia? *

Electrocardiogram Qt Prolonged: 31 people, 65.96%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 28 people, 59.57%
Arrhythmias (irregular heartbeat): 20 people, 42.55%
Tricuspid Valve Incompetence (inefficient heart valve): 20 people, 42.55%
Chest Pain: 20 people, 42.55%
Dry Mouth: 19 people, 40.43%
Pulmonary Valve Incompetence: 19 people, 40.43%
Dyspnea Exertional: 19 people, 40.43%
Heart Attack: 19 people, 40.43%
Dizziness: 19 people, 40.43%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 1 person, 2.13%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 2.13%
High Blood Pressure: 1 person, 2.13%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 2.13%
Arrhythmia Supraventricular (irregular heartbeat supraventricular origin): 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and have Sinus bradycardia?

- Check whether Sinus bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letrozole:

Letrozole (54,125 reports)

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus bradycardia:

Sinus bradycardia (901 drugs)

Browse all the conditions that are associated with Sinus bradycardia:

Sinus bradycardia (1,055 conditions)

Related publications that referenced our studies

Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Letrozole) and Letrozole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.