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Letrozole and Thrombophlebitis - a phase IV clinical study of FDA data

Summary:

Thrombophlebitis is reported as a side effect among people who take Letrozole (letrozole), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Ibrance, and have High blood pressure.

The phase IV clinical study analyzes which people have Thrombophlebitis when taking Letrozole. It is created by eHealthMe based on reports of 53,470 people who have side effects when taking Letrozole from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Thrombophlebitis?

Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot) is found to be associated with 945 drugs and 1,267 conditions by eHealthMe. Check the latest studies of Thrombophlebitis.



On Jul, 13, 2026

53,470 people reported to have side effects when taking Letrozole.
Among them, 56 people (0.1%) have Thrombophlebitis.

Could Letrozole cause Thrombophlebitis?

Among these 56 people:

How long have people been on Letrozole when they have Thrombophlebitis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Thrombophlebitis when taking Letrozole? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Thrombophlebitis when taking Letrozole? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 12.5 %
  • 50-59: 15.0 %
  • 60+: 72.5 %

What are other drugs people take besides Letrozole? *

  1. Ibrance: 17 people, 30.36%
  2. Pantoprazole: 13 people, 23.21%
  3. Palbociclib: 12 people, 21.43%
  4. Kisqali: 10 people, 17.86%
  5. Zometa: 10 people, 17.86%
  6. Innohep: 9 people, 16.07%
  7. Exemestane: 8 people, 14.29%
  8. Vitamin D: 8 people, 14.29%
  9. Ondansetron: 7 people, 12.50%
  10. Femara: 5 people, 8.93%

What are other side effects people have besides Thrombophlebitis? *

  1. Pulmonary Embolism (blockage of the main artery of the lung): 16 people, 28.57%
  2. Pain In Extremity: 14 people, 25.00%
  3. Anaemia (lack of blood): 10 people, 17.86%
  4. Blood Creatinine Increased: 10 people, 17.86%
  5. Nausea (feeling of having an urge to vomit): 10 people, 17.86%
  6. Diarrhea: 10 people, 17.86%
  7. Pain: 9 people, 16.07%
  8. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 9 people, 16.07%
  9. Fever: 8 people, 14.29%
  10. Nausea And Vomiting: 8 people, 14.29%

What are the existing conditions these people have? *

  1. High Blood Pressure: 17 people, 30.36%
  2. Constipation: 9 people, 16.07%
  3. Metastases To Bone (cancer spreads to bone): 6 people, 10.71%
  4. Diabetes: 6 people, 10.71%
  5. Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 4 people, 7.14%
  6. Sinusitis (inflammation of sinus): 3 people, 5.36%
  7. Thyroid Diseases: 3 people, 5.36%
  8. Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 3 people, 5.36%
  9. Breast Cancer Stage Iv: 2 people, 3.57%
  10. Blood Disorder: 2 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and have Thrombophlebitis?

- Check whether Thrombophlebitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Letrozole:

Thrombophlebitis treatments and more:

How severe was Thrombophlebitis and when was it recovered:

Expand to all the drugs that have ingredients of letrozole:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thrombophlebitis:

Browse all the conditions that are associated with Thrombophlebitis:


How the study uses the data?

The study uses data from the FDA. It is based on letrozole (the active ingredients of Letrozole) and Letrozole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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