Leukeran and Hepatic necrosis - a phase IV clinical study of FDA data

Summary:

Hepatic necrosis is reported as a side effect among people who take Leukeran (chlorambucil), especially for people who are male, 60+ old, also take Rituxan, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Hepatic necrosis when taking Leukeran. It is created by eHealthMe based on reports of 1,144 people who have side effects when taking Leukeran from the FDA, and is updated regularly.

What is Leukeran?

Leukeran has active ingredients of chlorambucil. eHealthMe is studying from 1,158 Leukeran users. Check the latest studies of Leukeran.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 594 drugs and 743 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.

On Jul, 19, 2026

1,144 people reported to have side effects when taking Leukeran.
Among them, 12 people (1.05%) have Hepatic necrosis.

Among these 12 people:

What is the gender of people who have Hepatic necrosis when taking Leukeran? *

female: 41.67 %
male: 58.33 %

What is the age of people who have Hepatic necrosis when taking Leukeran? *

What are other drugs people take besides Leukeran? *

What are other side effects people have besides Hepatic necrosis? *

Fever: 6 people, 50.00%
Ascites (accumulation of fluid in the abdominal cavity): 6 people, 50.00%
Liver Function Tests Nos Abnormal: 5 people, 41.67%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 4 people, 33.33%
Gamma-Glutamyltransferase Increased: 4 people, 33.33%
Gallstones (stone formation by bile component): 4 people, 33.33%
Hepatomegaly (abnormal enlargement of the liver): 4 people, 33.33%
Hepatotoxicity (chemical-driven liver damage): 4 people, 33.33%
International Normalised Ratio Increased: 4 people, 33.33%
Yellow Skin: 4 people, 33.33%

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Leukeran and have Hepatic necrosis?

- Check whether Hepatic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leukeran:

Leukeran (1,158 reports)

Browse all side effects of Leukeran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic necrosis:

Hepatic necrosis (594 drugs)

Browse all the conditions that are associated with Hepatic necrosis:

Hepatic necrosis (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on chlorambucil (the active ingredients of Leukeran) and Leukeran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.