Leukine and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Leukine (sargramostim), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Splenomegaly when taking Leukine. It is created by eHealthMe based on reports of 2,173 people who have side effects when taking Leukine from the FDA, and is updated regularly.

What is Leukine?

Leukine has active ingredients of sargramostim. eHealthMe is studying from 2,188 Leukine users. Check the latest studies of Leukine.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,122 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jul, 09, 2026

2,173 people reported to have side effects when taking Leukine.
Among them, 12 people (0.55%) have Splenomegaly.

Among these 12 people:

How long have people been on Leukine when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Leukine? *

female: 22.22 %
male: 77.78 %

What is the age of people who have Splenomegaly when taking Leukine? *

What are other drugs people take besides Leukine? *

What are other side effects people have besides Splenomegaly? *

Thrombocytopenia (decrease of platelets in blood): 7 people, 58.33%
Diarrhea: 5 people, 41.67%
Acute Kidney Failure: 4 people, 33.33%
Staphylococcal Infection (an infection with staphylococcus bacteria): 4 people, 33.33%
Hypotension (abnormally low blood pressure): 4 people, 33.33%
Cytomegalovirus Infection: 4 people, 33.33%
Dehydration (dryness resulting from the removal of water): 4 people, 33.33%
Mucosal Inflammation (infection of mucous membrane): 3 people, 25.00%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 3 people, 25.00%
Lower Gastrointestinal Haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding): 3 people, 25.00%

What are the existing conditions these people have? *

Haematopoietic Stem Cell Mobilisation: 3 people, 25.00%
Bone Marrow Conditioning Regimen: 3 people, 25.00%
Nausea And Vomiting: 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Flatulence (flatus expelled through the anus): 2 people, 16.67%
Dry Skin: 2 people, 16.67%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 16.67%
Prostate Cancer: 1 person, 8.33%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Leukine and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Leukine:

Leukine (2,188 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Leukine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,122 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sargramostim (the active ingredients of Leukine) and Leukine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.