Levetiracetam and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Levetiracetam (levetiracetam), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Gabapentin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Levetiracetam. It is created by eHealthMe based on reports of 74,747 people who have side effects when taking Levetiracetam from the FDA, and is updated regularly.

What is Levetiracetam?

Levetiracetam has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 75,292 Levetiracetam users. Check the latest studies of Levetiracetam.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,229 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 08, 2026

74,747 people reported to have side effects when taking Levetiracetam.
Among them, 17 people (0.02%) have Knee joint replacement.

Could Levetiracetam cause Knee joint replacement?

Among these 17 people:

How long have people been on Levetiracetam when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Levetiracetam? *

female: 58.82 %
male: 41.18 %

What is the age of people who have Knee joint replacement when taking Levetiracetam? *

What are other drugs people take besides Levetiracetam? *

What are other side effects people have besides Knee joint replacement? *

Joint Dislocation (a joint position is changed from normal position): 5 people, 29.41%
Fall: 3 people, 17.65%
Nausea (feeling of having an urge to vomit): 2 people, 11.76%
Gastric Disorder (disease of stomach): 2 people, 11.76%
Arthropathy: 2 people, 11.76%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 2 people, 11.76%
Skin Haemorrhage (bleeding into skin): 2 people, 11.76%
Rashes (redness): 2 people, 11.76%
Visual Impairment: 1 person, 5.88%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 5.88%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 23.53%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 17.65%
Type 2 Diabetes: 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Anaemia (lack of blood): 1 person, 5.88%
Asthma: 1 person, 5.88%
Constipation: 1 person, 5.88%
Diabetes: 1 person, 5.88%
Dry Eyes (lack of adequate tears): 1 person, 5.88%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Levetiracetam and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levetiracetam:

Levetiracetam (75,292 reports)

Browse all side effects of Levetiracetam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,229 conditions)

Related publications that referenced our studies

Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Levetiracetam) and Levetiracetam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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