Levetiracetam and Skull fracture - a phase IV clinical study of FDA data

Summary:

Skull fracture is reported as a side effect among people who take Levetiracetam (levetiracetam), especially for people who are male, 60+ old, also take Amlodipine, and have Cardiac disorder.

The phase IV clinical study analyzes which people have Skull fracture when taking Levetiracetam. It is created by eHealthMe based on reports of 74,747 people who have side effects when taking Levetiracetam from the FDA, and is updated regularly.

What is Levetiracetam?

Levetiracetam has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 75,292 Levetiracetam users. Check the latest studies of Levetiracetam.

What is Skull fracture?

Skull fracture is found to be associated with 245 drugs and 583 conditions by eHealthMe. Check the latest studies of Skull fracture.

On Jul, 18, 2026

74,747 people reported to have side effects when taking Levetiracetam.
Among them, 28 people (0.04%) have Skull fracture.

$Could Levetiracetam cause Skull fracture?$

Among these 28 people:

What is the gender of people who have Skull fracture when taking Levetiracetam? *

female: 17.39 %
male: 82.61 %

What is the age of people who have Skull fracture when taking Levetiracetam? *

What are other drugs people take besides Levetiracetam? *

What are other side effects people have besides Skull fracture? *

Fall: 13 people, 46.43%
Weakness: 12 people, 42.86%
Subdural Haematoma (blood collects between the skull and the surface of the brain): 10 people, 35.71%
Agitation (state of anxiety or nervous excitement): 8 people, 28.57%
Feeling Abnormal: 8 people, 28.57%
Drug Intolerance (drug sensitivity): 7 people, 25.00%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 7 people, 25.00%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 7 people, 25.00%
Dyspnea (difficult or laboured breathing): 7 people, 25.00%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 25.00%

What are the existing conditions these people have? *

Pain: 7 people, 25.00%
High Blood Pressure: 7 people, 25.00%
Cardiac Disorder: 7 people, 25.00%
Abdominal Pain Upper: 6 people, 21.43%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 21.43%
Acute Kidney Failure: 6 people, 21.43%
Primary Myelofibrosis (primary disorder of the bone marrow): 6 people, 21.43%
Folate Deficiency (lack of folic acid): 6 people, 21.43%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 21.43%
Cardiac Failure: 6 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Do you take Levetiracetam and have Skull fracture?

- Check whether Skull fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levetiracetam:

Levetiracetam (75,292 reports)

Skull fracture treatments and more:

Skull fracture (2,009 reports)

Browse all side effects of Levetiracetam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skull fracture:

Skull fracture (245 drugs)

Browse all the conditions that are associated with Skull fracture:

Skull fracture (583 conditions)

Related publications that referenced our studies

Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on levetiracetam (the active ingredients of Levetiracetam) and Levetiracetam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.