Levo-t and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Levo-t (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lidocaine Hydrochloride, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Headache when taking Levo-t. It is created by eHealthMe based on reports of 633 people who have side effects when taking Levo-t from the FDA, and is updated regularly.

What is Levo-t?

Levo-t has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 961 Levo-t users. Check the latest studies of Levo-t.

What is Headache?

Headache (pain in head) is found to be associated with 3,752 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Apr, 25, 2026

633 people reported to have side effects when taking Levo-t.
Among them, 32 people (5.06%) have Headache.

Among these 32 people:

How long have people been on Levo-t when they have Headache? *

What is the gender of people who have Headache when taking Levo-t? *

female: 96.67 %
male: 3.33 %

What is the age of people who have Headache when taking Levo-t? *

What are other drugs people take besides Levo-t? *

Zyrtec: 2 people, 6.25%
Amitriptyline Hydrochloride: 2 people, 6.25%
Remodulin: 2 people, 6.25%
Ketamine Hydrochloride: 2 people, 6.25%
Clonidine: 2 people, 6.25%
Lecithin: 2 people, 6.25%
Ketoprofen: 2 people, 6.25%
Vitamin D: 2 people, 6.25%
Vitamin D3: 2 people, 6.25%
Lidocaine Hydrochloride: 2 people, 6.25%

What are other side effects people have besides Headache? *

Nausea (feeling of having an urge to vomit): 5 people, 15.62%
Pain: 5 people, 15.62%
Fatigue (feeling of tiredness): 5 people, 15.62%
Weakness: 4 people, 12.50%
Muscle Spasms (muscle contraction): 4 people, 12.50%
Diarrhea: 4 people, 12.50%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 4 people, 12.50%
Chest Pain: 4 people, 12.50%
Joint Pain: 3 people, 9.38%
Muscle Aches (muscle pain): 3 people, 9.38%

What are the existing conditions these people have? *

Thyroid Diseases: 2 people, 6.25%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 6.25%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 1 person, 3.12%
Neoplasm Malignant (cancer tumour): 1 person, 3.12%
Myositis (inflammation of the muscles): 1 person, 3.12%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.12%
Insomnia (sleeplessness): 1 person, 3.12%
Immunodeficiency Common Variable: 1 person, 3.12%
High Blood Pressure: 1 person, 3.12%
Gastrointestinal Stromal Tumor: 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Levo-t and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levo-t:

Levo-t (961 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Levo-t:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,752 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,772 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levo-t) and Levo-t (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.