Levofloxacin and Clostridium difficile colitis - a phase IV clinical study of FDA data

Summary:

Clostridium difficile colitis is reported as a side effect among people who take Levofloxacin (levofloxacin; sodium chloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have High blood pressure.

The phase IV clinical study analyzes which people have Clostridium difficile colitis when taking Levofloxacin. It is created by eHealthMe based on reports of 15,872 people who have side effects when taking Levofloxacin from the FDA, and is updated regularly.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

What is Clostridium difficile colitis?

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection) is found to be associated with 1,042 drugs and 1,782 conditions by eHealthMe. Check the latest studies of Clostridium difficile colitis.

On Jul, 20, 2026

15,872 people reported to have side effects when taking Levofloxacin.
Among them, 92 people (0.58%) have Clostridium difficile colitis.

Could Levofloxacin cause Clostridium difficile colitis?

Among these 92 people:

How long have people been on Levofloxacin when they have Clostridium difficile colitis? *

What is the gender of people who have Clostridium difficile colitis when taking Levofloxacin? *

female: 60.47 %
male: 39.53 %

What is the age of people who have Clostridium difficile colitis when taking Levofloxacin? *

What are other drugs people take besides Levofloxacin? *

What are other side effects people have besides Clostridium difficile colitis? *

Acute Kidney Failure: 14 people, 15.22%
Hypotension (abnormally low blood pressure): 9 people, 9.78%
Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 9.78%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 9 people, 9.78%
Blood Creatinine Increased: 8 people, 8.70%
Staphylococcal Infection (an infection with staphylococcus bacteria): 8 people, 8.70%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 7 people, 7.61%
Dehydration (dryness resulting from the removal of water): 7 people, 7.61%
Encephalopathy (functioning of the brain is affected by some agent or condition): 7 people, 7.61%
Fever: 7 people, 7.61%

What are the existing conditions these people have? *

High Blood Pressure: 23 people, 25.00%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 8 people, 8.70%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 7.61%
Pain: 7 people, 7.61%
Diabetes: 5 people, 5.43%
Insomnia (sleeplessness): 5 people, 5.43%
Multiple Myeloma (cancer of the plasma cells): 5 people, 5.43%
Nausea (feeling of having an urge to vomit): 5 people, 5.43%
Diarrhea: 5 people, 5.43%
Type 2 Diabetes: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Levofloxacin and have Clostridium difficile colitis?

- Check whether Clostridium difficile colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levofloxacin:

Levofloxacin (16,335 reports)

Browse all side effects of Levofloxacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,042 drugs)

Browse all the conditions that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,782 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levofloxacin; sodium chloride (the active ingredients of Levofloxacin) and Levofloxacin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.