Levoleucovorin calcium and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Levoleucovorin calcium (levoleucovorin calcium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Actemra, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Headache when taking Levoleucovorin calcium. It is created by eHealthMe based on reports of 2,464 people who have side effects when taking Levoleucovorin calcium from the FDA, and is updated regularly.

What is Levoleucovorin calcium?

Levoleucovorin calcium has active ingredients of levoleucovorin calcium. eHealthMe is studying from 2,464 Levoleucovorin calcium users. Check the latest studies of Levoleucovorin calcium.

What is Headache?

Headache (pain in head) is found to be associated with 3,753 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 14, 2026

2,464 people reported to have side effects when taking Levoleucovorin calcium.
Among them, 18 people (0.73%) have Headache.

Could Levoleucovorin calcium cause Headache?

Among these 18 people:

How long have people been on Levoleucovorin calcium when they have Headache? *

What is the gender of people who have Headache when taking Levoleucovorin calcium? *

female: 94.44 %
male: 5.56 %

What is the age of people who have Headache when taking Levoleucovorin calcium? *

What are other drugs people take besides Levoleucovorin calcium? *

What are other side effects people have besides Headache? *

Weight Decreased: 13 people, 72.22%
Body Temperature Decreased: 13 people, 72.22%
Nausea (feeling of having an urge to vomit): 13 people, 72.22%
High Blood Pressure: 8 people, 44.44%
Oedema Peripheral (superficial swelling): 7 people, 38.89%
Pancreatitis (inflammation of pancreas): 7 people, 38.89%
Gingival Bleeding (bleeding gums): 7 people, 38.89%
Hepatitis (inflammation of the liver): 7 people, 38.89%
Vaginal Infection: 7 people, 38.89%
Migraine (headache): 7 people, 38.89%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 72.22%
Vaginal Infection: 7 people, 38.89%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 33.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.56%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 1 person, 5.56%
Rectal Cancer (cancer of rectum): 1 person, 5.56%
Otitis (ear infection): 1 person, 5.56%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.56%
Nausea (feeling of having an urge to vomit): 1 person, 5.56%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Levoleucovorin calcium and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levoleucovorin calcium:

Levoleucovorin calcium (2,464 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Levoleucovorin calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,753 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,772 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levoleucovorin calcium (the active ingredients of Levoleucovorin calcium) and Levoleucovorin calcium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.